Results 61 to 70 of about 104,390 (258)
Salud Pública de México, 2004 El factor de crecimiento transformante beta (TGF-beta) es una familia de proteínas que incluye al TGF-beta, activinas y a la proteína morfogénica de hueso (BMP, por sus siglas en inglés), citocinas que son secretadas y se relacionan estructuralmente en ...
Francisco Javier Gálvez-Gastélum +2 more
doaj
CYCLOSPORIN A ACTIVATES TGF-/SMAD SIGNALING PATHWAY IN RAT LIVER [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2014 Cyclosporin A (CsA) is one of the most important immunosuppressive agents and therefore is widely used in organ transplantation. However, the clinical use of CsA is strongly limited by several side effects including hepatotoxicity which remains a major ...
El-Sayed Akool
doaj +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Cinnamophilin ameliorates testosterone-induced prostatic hyperplasia and fibrosis by regulating 5α-reductase and TGF-β/Smad signaling pathway [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Androgen and TGF-β1/Smad signaling pathways play important roles in epithelial-mesenchymal transition (EMT), fibrosis, and the development of benign prostatic hyperplasia (BPH). Cinnamophilin is extracted from Cinnamomum philippinense.
Di Han +12 more
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Advanced Science, EarlyView.ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao +7 more
wiley +1 more source
Transcriptional Control by the SMADs [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 The transforming growth factor-β (TGF-β) family of ligands elicit their biological effects by initiating new programs of gene expression. The best understood signal transducers for these ligands are the SMADs, which essentially act as transcription factors that are activated in the cytoplasm and then accumulate in the nucleus in response to ligand ...
openaire +2 more sources
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Pharmacogenomics and Personalized Medicine, 2020 Jinjie Yu,1,* Yunpeng Dong,1,* Weifeng Tang,2 Huiwen Pan,2 Lu Lv,2 Tao Long,2 Qiang Zhou,2 Junqing Qi,2 Jianchao Liu,2 Guowen Ding,2 Jun Yin,1 Lijie Tan1 1Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s ...
Yu J +11 more
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Molecular Therapy: Nucleic Acids, 2017 Liver fibrosis is characterized by changes in tissue architecture and extracellular matrix composition. Liver fibrosis affects not only hepatocytes but also the non-parenchymal cells such as hepatic stellate cells (HSCs), which are essential for ...
Jung-Yeon Kim +6 more
doaj +1 more source