Results 21 to 30 of about 166,768 (353)

Modulation of bone morphogenetic protein activity by melatonin in ovarian steroidogenesis

Reproductive Medicine and Biology, 2018
Background Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a
Fumio Otsuka
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Myostatin Increases Smad2 Phosphorylation and Atrogin-1 Expression in Chick Embryonic Myotubes

The Journal of Poultry Science, 2019
Skeletal muscle mass is an important trait in poultry meat production. In mammals, myostatin, a negative regulator of skeletal muscle growth, activates Smad transcription factors and induces the expression of atrogin-1 by regulating the Akt/FOXO pathway.
Takaoki Saneyasu, Kazuhisa Honda, Hiroshi Kamisoyama   +2 more
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ZC4H2 stabilizes Smads to enhance BMP signalling, which is involved in neural development in Xenopus [PDF]

Open Biology, 2017
Bone morphogenetic proteins (BMPs) play vital roles in regulating stem cell maintenance, differentiation and embryonic development. Intracellularly, BMP signalling is mediated by Smad proteins, which are regulated post-transcriptionally through ...
Pengcheng Ma, Biyu Ren, Xiangcai Yang, Bin Sun, Xiaoliang Liu, Qinghua Kong, Chaocui Li, Bingyu Mao   +7 more
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miR-192 inhibits the activation of hepatic stellate cells by targeting Rictor

Open Medicine, 2023
The activation of hepatic stellate cells (HSCs) is regarded as the primary driving factor of liver fibrosis. miR-192, a miRNA associated with hepatocellular carcinoma and enriched in HSCs, has an undisclosed role in HSC activation and liver fibrosis.
Kang Hui, Luo Jie, Wang Chun, Hong Yinghui, Ye Mingliang, Ding Yang, Zhao Qiu, Chang Ying   +7 more
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Phospho-Smad3 signaling is predictive biomarker for hepatocellular carcinoma risk assessment in primary biliary cholangitis patients

Frontiers in Bioscience-Landmark, 2021
Introduction: Patients with primary biliary cholangitis (PBC) are at increased risk for development of hepatocellular carcinoma (HCC), particularly in the presence of comorbidities such as excessive alcohol consumption.
Naohiro Nakamura, Katsunori Yoshida, Rinako Tsuda, Miki Murata, Takashi Yamaguchi, Kanehiko Suwa, Mayuko Ichimura, Koichi Tsuneyama, Koichi Matsuzaki, Toshiaki Nakano, Junko Hirohara, Toshihito Seki, Kazuichi Okazaki, M. Eric Gershwin, Makoto Naganuma   +14 more
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It’s a SMAD, SMAD World

JACC: Basic to Translational Science, 2019
[Figure: see text]
openaire   +3 more sources

GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype

Cells, 2020
Macrophages are critical for regulation of inflammatory response during endotoxemia and septic shock. However, the mediators underlying their regulatory function remain obscure.
Lu Wang, Yutian Li, Xiaohong Wang, Peng Wang, Kobina Essandoh, Shunan Cui, Wei Huang, Xingjiang Mu, Zhenling Liu, Yigang Wang, Tianqing Peng, Guo-Chang Fan   +11 more
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Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal

Fly, 2017
Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration.
Aiguo Tian, Jin Jiang
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Smad signalling in the ovary [PDF]

Reproductive Biology and Endocrinology, 2006
Abstract It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transforming growth factor beta (TGF-beta) superfamily.
Kaivo-Oja, N., Jeffrey, L., Ritvos, O., Mottershead, D.   +3 more
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TSG-6 Inhibits the Growth of Keloid Fibroblasts Via Mediating the TGF-β1/Smad Signaling Pathway

Journal of Investigative Surgery, 2021
Background The cytokine TNF-α-stimulated gene-6 (TSG-6) had been verified to have a certain inhibitory effect on the inflammation. During wound healing, fibroblasts increasingly proliferated and deposited collagen fibers, leading to the formation of ...
Xin-Yi Li, Xiao-Juan Weng, Xiao-Jing Li, Xiao-Yu Tian   +3 more
doaj   +1 more source