Results 11 to 20 of about 335,996 (268)

miR-24 and miR-122 Negatively Regulate the Transforming Growth Factor-β/Smad Signaling Pathway in Skeletal Muscle Fibrosis

Molecular Therapy: Nucleic Acids, 2018
Fibrosis is common after skeletal muscle injury, undermining tissue regeneration and function. The mechanism underlying skeletal muscle fibrosis remains unveiled.
Yaying Sun, Hui Wang, Yan Li, Shaohua Liu, Jiwu Chen, Hao Ying   +5 more
doaj   +1 more source

Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis

Open Biology, 2021
Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this ...
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin   +4 more
doaj   +1 more source

Transforming growth factor-β in diabetic nephropathy

The Egyptian Journal of Internal Medicine, 2013
Background Renal failure is a common and serious complication of long-standing diabetes mellitus. Diabetes is the most common cause of end-stage renal failure.
Karima Y. Ahmed, Walaa F. El-Bazz, Hend A. Mohamed, Maha M. Elkeshky   +3 more
doaj   +1 more source

TRANSFORMING GROWTH FACTOR 1 AT LIVER TRANSPLANTATION

Вестник трансплантологии и искусственных органов, 2015
This review summarizes the current literature devoted to the analysis of the role of transforming growth factor beta 1 (TGF-β1) at liver transplantation.
R. M. Kurabekova, O. P. Shevchenko, O. M. Tsiroulnikova   +2 more
doaj   +1 more source

Transforming Growth Factor-Beta1 in Diabetic Kidney Disease

Frontiers in Cell and Developmental Biology, 2020
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Renin-angiotensin-aldosterone system (RAAS) inhibitors and sodium-glucose co-transporter 2 (SGLT2) inhibitors have shown efficacy in reducing the risk of ESRD.
Lijun Zhao, Yutong Zou, Fang Liu
doaj   +1 more source

Transforming growth factor-β in graft vessels: histology and immunohistochemistry

Clinics, 2011
OBJECTIVES: The biological functions of transforming growth factor-β signaling that involves Smad proteins have not been previously investigated with respect to coronary artery bypass grafts.
Shi-Min Yuan, Yan-Qing Wang, Yi Shen, Hua Jing   +3 more
doaj   +1 more source

Transforming growth factor-β1/Smad/connective tissue growth factor axis: The main pathway in radiation-induced fibrosis of osteoradionecrosis?

Dental Hypotheses, 2013
Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after ...
Qian Wei Zhuang, Zhi Yuan Zhang, Guang Long Liu, Shui Ting Fu, Yue He   +4 more
doaj   +1 more source

Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

Brazilian Journal of Otorhinolaryngology, 2014
Introduction: Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors.
Marco Antonio dos Anjos Corvo, Claudia Alessandra Eckley, Luis Vicente Rizzo, Luiz Roberto Sardinha, Tomas Navarro Rodriguez, Ivo Bussoloti Filho   +5 more
doaj   +1 more source

Canine Transforming Growth Factor-β Receptor 2-Ig: A Potential Candidate Biologic for Melanoma Treatment That Reverses Transforming Growth Factor-β1 Immunosuppression

Frontiers in Veterinary Science, 2021
Cancer cells can evade host immune systems via multiple mechanisms. Transforming growth factor beta 1 (TGF-β1) is an immunosuppressive cytokine that induces regulatory T cell (Tregs) differentiation and is involved in immune evasion mechanisms in cancer.
Hiroto Takeuchi, Satoru Konnai, Satoru Konnai, Naoya Maekawa, Satoshi Takagi, Satoshi Takagi, Hiroshi Ohta, Noboru Sasaki, Sangho Kim, Tomohiro Okagawa, Yasuhiko Suzuki, Yasuhiko Suzuki, Yasuhiko Suzuki, Shiro Murata, Shiro Murata, Kazuhiko Ohashi, Kazuhiko Ohashi   +16 more
doaj   +1 more source

Transforming growth factor- : transforming plaque to stability [PDF]

European Heart Journal, 2012
This editorial refers to ‘Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis’, by D. Lievens et al., doi:10.1093/eurheartj/ehs106 Lievens and colleagues report an important finding that helps to elucidate the role of transforming ...
Kevin, Tse, Klaus, Ley
openaire   +2 more sources