Results 1 to 10 of about 1,962,623 (304)

Epidermal Growth Factor

Journal of Investigative Dermatology, 1972
During the course of the studies on the nerve growth factor of the submaxillary gland of the male mouse (1), it was observed that extracts of these glands, when injected into newborn mice, caused precocious opening of the eyelid and eruption of the incisors. A polypeptide responsible for this effect has been isolated (2).
John M. Taylor, William M. Mitchell, Stanley Cohen   +2 more
semanticscholar   +5 more sources

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

Cancers, 2017
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, glioblastoma, head and neck cancer, pancreatic cancer, and breast ...
Zhixiang Wang, Ping Wee, Wang Zhixiang   +2 more
exaly   +2 more sources

Pharmacology of Epidermal Growth Factor Inhibitors

The International Journal of Biological Markers, 2007
Research into the molecular bases of malignant diseases has yielded the development of many novel agents with potential antitumor activity. Evidence for a causative role for the epidermal growth factor receptor (EGFR), which is now regarded as an ...
G. Toffoli MD, E. De Mattia, E. Cecchin, P. Biason, S. Masier, G. Corona   +5 more
doaj   +4 more sources

Epidermal Growth Factor and Intestinal Barrier Function

Mediators of Inflammation, 2016
Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation.
Xiaopeng Tang, Hu Liu, Shufen Yang, Zuohua Li, Jinfeng Zhong, Rejun Fang   +5 more
doaj   +2 more sources

Epidermal growth factor receptor: Role in human cancer

Indian Journal of Dental Research, 2017
Cells are constantly exposed to various external stimuli which regulate the growth and survival of the cells. The signal transduction from the external environment to the interior of the cell is carried out by cell surface or transmembrane receptors ...
Prashanth Rajaram, Poornima Chandra, Smriti Ticku, B K Pallavi, K B Rudresh, Poorva Mansabdar   +5 more
doaj   +2 more sources

Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation

Nature Communications, 2022
Epidermal growth factor is an excellent drug for promoting wound healing; however, its conventional administration strategies are associated with pharmacodynamic challenges, such as low transdermal permeability, reduction, and receptor desensitization ...
Yuan Yang, Ruizeng Luo, Shengyu Chao, Jiangtao Xue, Dongjie Jiang, Yun Hao Feng, X. Guo, Danling Luo, Jiaping Zhang, Zhou Li, Z. Wang   +10 more
semanticscholar   +1 more source

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

Neural Regeneration Research, 2022
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s disease.
Heba M Mansour, Hala M Fawzy, Aiman S El-Khatib, Mahmoud M Khattab   +3 more
doaj   +1 more source

The use of epidermal growth factor in dermatological practice

International Wound Journal, 2022
Epidermal growth factor (EGF) is a growth factor that plays a pivotal role in wound healing and maintaining tissue homeostasis by regulating cell survival, proliferation, migration, and differentiation.
Sun-Hye Shin, Young Gue Koh, Woo Geon Lee, J. Seok, K. Park   +4 more
semanticscholar   +1 more source

An EGFR T790M-mutated lung adenocarcinoma undergoing large-cell neuroendocrine carcinoma transformation after osimertinib therapy: a case report

Journal of Medical Case Reports, 2020
Background Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is selective for both epidermal growth factor receptor tyrosine kinase inhibitor–sensitizing and T790M resistance mutations.
Shinichi Miyazaki, Yasumasa Kuno, Shunsaku Hayai, Ryo Teramachi, Ryo Yamashita, Yusuke Saito, Kosuke Higuchi, Yoshiharu Nara, Takuya Ikeda   +8 more
doaj   +1 more source

Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer

Seminars in Cancer Biology, 2020
Epidermal growth factor receptor (EGFR) mutations are the second most common oncogenic driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 deletions and the L858R point mutation) comprise the vast majority of EGFR ...
Peter T. Harrison, S. Vyse, Paul H. Huang   +2 more
semanticscholar   +1 more source