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The Role of ErbB Receptors in Infection [PDF]

Trends in Microbiology, 2017
Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Jemima Ho, David L Moyes, Mahvash Tavassoli   +2 more
exaly   +7 more sources

Targeting erbB receptors [PDF]

Seminars in Cell and Developmental Biology, 2010
Our work is concerned with the origins and therapy of human cancers. Members of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, also known as erbB or HER receptors, are over expressed and/or activated in many types of human tumors and represent important therapeutic targets in cancer therapy.
Zheng Cai, Hongtao Zhang, Alan Berezov   +2 more
exaly   +5 more sources

Role of ErbB receptors in cancer cell migration and invasion [PDF]

Frontiers in Pharmacology, 2015
Growth factors mediate their diverse biologic responses (regulation of cellular proliferation, differentiation, migration and survival) by binding to and activating cell-surface receptors with intrinsic protein kinase activity named Receptor Tyrosine ...
Aline eAppert-Collin, Pierre eHubert, Gerard eCremel, Amar eBennasroune, Amar eBennasroune   +4 more
doaj   +4 more sources

Regulation of ErbB Receptors by the Ca²⁺ Sensor Protein Calmodulin in Cancer [PDF]

Biomedicines, 2023
Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory ...
Antonio Villalobo
doaj   +2 more sources

Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma [PDF]

Frontiers in Medicine, 2023
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is ...
Camilla Palumbo, Monica Benvenuto, Monica Benvenuto, Chiara Focaccetti, Loredana Albonici, Loredana Cifaldi, Loredana Cifaldi, Alessandra Rufini, Alessandra Rufini, Daniela Nardozi, Valentina Angiolini, Arianna Bei, Laura Masuelli, Roberto Bei   +13 more
doaj   +2 more sources

 Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo [PDF]

Journal of Translational Medicine, 2022
Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM.
Roberto Bei, Monica Benvenuto, Chiara Focaccetti, Sara Fazi, Marta Moretti, Daniela Nardozi, Valentina Angiolini, Sara Ciuffa, Loredana Cifaldi, Raffaele Carrano, Camilla Palumbo, Martino Tony Miele, Riccardo Bei, Giovanni Barillari, Vittorio Manzari, Enrico De Smaele, Andrea Modesti, Laura Masuelli   +17 more
doaj   +2 more sources

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists [PDF]

iScience
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr   +10 more
doaj   +2 more sources

Regulation of sebaceous gland homeostasis and sebum secretion by the ERBB receptor family [PDF]

iScience
Summary: ERBB receptors are underappreciated regulators of cellular processes in the sebaceous gland (SG). They control sebocyte proliferation, differentiation, and lipid production - mechanisms that are essential for SG homeostasis, sebum secretion, and
Theresa Hommel, Marlon R. Schneider, Maik Dahlhoff   +2 more
doaj   +2 more sources

Relationships between progesterone receptor isoforms and the HER/ErbB receptors and ligands network in 299 primary breast cancers

The International Journal of Biological Markers, 2012
Background The effects of progesterone are mediated by 2 progesterone receptors (PR), PR-A and PR-B. Recently, several lines of evidence have suggested that reduced PR expression may result from hyperactivity in the signaling cascade generated by the HER/
Clothilde Lindet, Françoise Révillion, Valérie Lhotellier, Louis Hornez, Jean-Philippe Peyrat, Jacques Bonneterre MD, PhD   +5 more
doaj   +2 more sources

ERBB receptors in cancer: signaling from the inside. [PDF]

Breast Cancer Res, 2011
ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family.
Arteaga CL.
europepmc   +4 more sources