Results 41 to 50 of about 36,079 (213)
The Dumb ErbB Receptor Helps Healing [PDF]
Journal of Investigative Dermatology, 2007 ErbB3 receptor is a member of the epidermal growth factor (EGF) receptor (ErbB1) family. Okwueze et al. have transfected this receptor in a pig model of wounds and demonstrate that it accelerates the resurfacing of the wounds when combined with epiregulin or heparin-binding EGF. Currently, only hypotheses can be proposed to explain the observations.
openaire +3 more sources
Targeting the Calmodulin-Regulated ErbB/Grb7 Signaling Axis in Cancer Therapy
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Signal transduction pathways essential for the survival and viability of the cell and that frequently present aberrant expression or function in tumors are attractive targets for pharmacological intervention in human cancers. In this short review we will
Antonio Villalobo +3 more
doaj +1 more source
The complete family of epidermal growth factor receptors and their ligands are co-ordinately expressed in breast cancer [PDF]
, 2009 The levels of expression of the four receptors and eleven ligands composing the Epidermal Growth Factor family were measured using immunohistochemical staining in one hundred cases of breast cancer. All of the family were expressed to some degree in some
McIntyre, Emmet +4 more
core +1 more source
Scientific Reports, 2017 Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri +2 more
doaj +1 more source
The ErbB2 receptor and breast carcinoma cell migration : memo is a novel mediator of cell motility [PDF]
, 2003 The ErbB family of receptor tyrosine kinases play important role in normal physiological processes occurring during development; moreover, their deregulated expression has been implicated in human cancer. Cancer patients, whose tumors have alterations in
Marone, Romina
core +1 more source
PLoS ONE, 2012 First-generation interaction maps of Src homology 2 (SH2) domains with receptor tyrosine kinase (RTK) phosphosites have previously been generated using protein microarray (PM) technologies.
Ronald J Hause +5 more
doaj +1 more source
Combinatorial strategy using protein kinase inhibitors and a cytotoxic compound for highly resistant glioblastoma cells : "in vitro studies" [PDF]
, 2007 Glioblastoma multiforme (GBM) is the most frequent and the most aggesssive malignant neoplasm of the human central nervous system (CNS), with a median survival of less than one year. These neoplasms are radio- and chemo-resistant, and are highly invasive,
Failly, Mike
core +1 more source
Ligand-induced ErbB receptor dimerization [PDF]
Experimental Cell Research, 2009 Structural studies have provided important new insights into how ligand binding promotes homodimerization and activation of the EGF receptor and the other members of the ErbB family of receptor tyrosine kinases. These structures have also suggested possible explanations for the unique properties of ErbB2, which has no known ligand and can cause cell ...
openaire +2 more sources
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4 [PDF]
Oncogene, 1997 Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling.
T, Komurasaki +3 more
openaire +2 more sources
Cell Death and Disease, 2022 Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2.
Santiago Madera +18 more
doaj +1 more source