Results 11 to 20 of about 54,427 (226)

Role of ErbB receptors in cancer cell migration and invasion [PDF]

Frontiers in Pharmacology, 2015
Growth factors mediate their diverse biologic responses (regulation of cellular proliferation, differentiation, migration and survival) by binding to and activating cell-surface receptors with intrinsic protein kinase activity named Receptor Tyrosine ...
Aline eAppert-Collin, Pierre eHubert, Gerard eCremel, Amar eBennasroune, Amar eBennasroune   +4 more
doaj   +4 more sources

Regulation of ErbB Receptors by the Ca²⁺ Sensor Protein Calmodulin in Cancer [PDF]

Biomedicines, 2023
Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory ...
Antonio Villalobo
doaj   +2 more sources

Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma [PDF]

Frontiers in Medicine, 2023
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is ...
Camilla Palumbo, Monica Benvenuto, Monica Benvenuto, Chiara Focaccetti, Loredana Albonici, Loredana Cifaldi, Loredana Cifaldi, Alessandra Rufini, Alessandra Rufini, Daniela Nardozi, Valentina Angiolini, Arianna Bei, Laura Masuelli, Roberto Bei   +13 more
doaj   +2 more sources

The Role of ErbB Receptors in Infection. [PDF]

Trends Microbiol, 2017
Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Ho J, Moyes DL, Tavassoli M, Naglik JR.
europepmc   +9 more sources

 Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo [PDF]

Journal of Translational Medicine, 2022
Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM.
Roberto Bei, Monica Benvenuto, Chiara Focaccetti, Sara Fazi, Marta Moretti, Daniela Nardozi, Valentina Angiolini, Sara Ciuffa, Loredana Cifaldi, Raffaele Carrano, Camilla Palumbo, Martino Tony Miele, Riccardo Bei, Giovanni Barillari, Vittorio Manzari, Enrico De Smaele, Andrea Modesti, Laura Masuelli   +17 more
doaj   +2 more sources

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]

PLoS ONE, 2012
During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Emanuelle Donier, Jose Antonio Gomez-Sanchez, Carmen Grijota-Martinez, Jarmila Lakomá, Sigrid Baars, Luis Garcia-Alonso, Hugo Cabedo   +6 more
doaj   +4 more sources

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists [PDF]

iScience
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr   +10 more
doaj   +2 more sources

Regulation of sebaceous gland homeostasis and sebum secretion by the ERBB receptor family [PDF]

iScience
Summary: ERBB receptors are underappreciated regulators of cellular processes in the sebaceous gland (SG). They control sebocyte proliferation, differentiation, and lipid production - mechanisms that are essential for SG homeostasis, sebum secretion, and
Theresa Hommel, Marlon R. Schneider, Maik Dahlhoff   +2 more
doaj   +2 more sources

Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis. [PDF]

PLoS ONE, 2010
The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is
Victoria E Abraira, Takunori Satoh, Donna M Fekete, Lisa V Goodrich   +3 more
doaj   +4 more sources

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4 [PDF]

Oncogene, 1997
Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling.
T, Komurasaki, H, Toyoda, D, Uchida, S, Morimoto   +3 more
openaire   +4 more sources