Results 161 to 170 of about 2,112,620 (360)

Additional file 7: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

, 2019
Table S2. SILAC of differential proteins in HepG2-RNF38 and HepG2-vector (Up-regulated) (DOCX 43 kb)
Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia   +13 more
openaire   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Additional file 5: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

, 2019
Figure S3. The AHNAK expression in HCCLM3 and HCCLM3-siAHNAK cells. Western blot showed that the expression of AHNAK after transfecting the short interfering RNA to HCCLM3. (PDF 152 kb)
Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia   +13 more
openaire   +1 more source

UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation and Does Not Affect Tumor-response to Irradiation

American Journal of Biomedical Sciences, 2014
UTL-5g is a small-molecule TNF- inhibitor having chemoprotective and liver radioprotective effects. We investigated the effects of UTL-5g on lung irradiated mice and whether UTL-5g affects tumor responses to radiotherapy. C57BL/6 mice were individually treated with UTL-5g at 15, 30, and 60 mg/kg and amifostine (200 mg/kg) by i.p.
Stephen Brown, Frederick Valeriote, Ben Chen, Kevin Bobbitt, Joseph Media, Halina Pietraszkiewicz, Jiajiu Shaw   +6 more
openaire   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

Frontiers in Pharmacology, 2017
Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and degradation. Excessive ECM deposition results in scarring and thickening of the affected tissue, and interferes with tissue and organ homeostasis – mimicking an ...
K. Walton, Katharine E. Johnson, C. Harrison   +2 more
semanticscholar   +1 more source

Additional file 2: of Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis

, 2018
Figure S2. HPH-15 treatment did not affect the growing of the mice. The body weight changes of mice treated with vehicle or HPH-15 were assessed every 3 days. All values represent mean Âą SEM; n = 5 in each group. (PDF 6 kb)
Luong, Vu, Takenao Chino, Oyama, Noritaka, Matsushita, Takashi, Sasaki, Yoko, Ogura, Dai, Shin-Ichiro Niwa, Tanima Biswas, Akiyuki Hamasaki, Fujita, Mikako, Okamoto, Yoshinari, Otsuka, Masami, Ihn, Hironobu, Hasegawa, Minoru   +13 more
openaire   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

Redox Biology, 2015
Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its expression is increased in almost all of fibrotic diseases.
Rui‐Ming Liu, L. Desai
semanticscholar   +1 more source