Results 111 to 120 of about 2,112,620 (360)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

ATBF1 Participates in Dual Functions of TGF-β via Regulation of Gene Expression and Protein Translocalization

Biomolecules, 2020
TGF-β is a critical cytokine to regulate multiple pathophysiological functions. For tumor development and progression, TGF-β was reported to play dual functions as a tumor suppressor and epithelial-mesenchymal transition (EMT) inducer.
Mei Li, Anqi Zhang, Yanan Zheng, Jiajing Li, Jiyuan Zhao   +4 more
doaj   +1 more source

Additional file 3: of FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

, 2017
Figure S3. Upregulation of FUT8 is associated with poor prognosis in breast cancer patients. (PDF 41 kb)
Cheng-Fen Tu, Meng-Ying Wu, Yuh-Charn Lin, Kannagi, Reiji, Ruey-Bing Yang   +4 more
openaire   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity

Cell Reports, 2019
Summary: Molecular processes involving lncRNAs regulate cell function. By applying transcriptomics, we identify lncRNAs whose expression is regulated by transforming growth factor β (TGF-β).
Panagiotis Papoutsoglou, Yutaro Tsubakihara, Laia Caja, Anita Morén, Paris Pallis, Adam Ameur, Carl-Henrik Heldin, Aristidis Moustakas   +7 more
doaj   +1 more source

Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. [PDF]

PLoS ONE, 2013
Hepatocellular carcinoma (HCC) is a major public health problem due to increased incidence, late diagnosis and limited treatment options. TGF-β is known to provide cytostatic signals during early stages of liver damage and regeneration, but exerts tumor ...
Johanna Dzieran, Jasmin Fabian, Teng Feng, Cédric Coulouarn, Iryna Ilkavets, Anastasia Kyselova, Kai Breuhahn, Steven Dooley, Nadja M Meindl-Beinker   +8 more
doaj   +1 more source

Additional file 2: of FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation

, 2017
Figure S2. FUT8 expression in invasive or metastatic breast cancers. (PDF 48 kb)
Cheng-Fen Tu, Meng-Ying Wu, Yuh-Charn Lin, Kannagi, Reiji, Ruey-Bing Yang   +4 more
openaire   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1 [PDF]

, 2011
Background Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth
Hendrik Ungefroren, Stephanie Groth, Susanne Sebens, Hendrik Lehnert, Frank Gieseler, Fred Fändrich   +5 more
core   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source