Results 111 to 120 of about 13,045 (219)

Additional file 1: of The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma

, 2019
Figure S1. LEF1 and ID1 expression in ESCC samples and the transcription of ID1 is regulated by LEF1. (A) LEF1 and ID1 staining by IHC in ESCC TMAs were showed. Upper panel was used for analysis of expression association between LEF1 and ID1.A total of 243 LEF1 staining patients were used for clinicopathological characteristics analysis.
Zhao, Yue, Zhu, Ji, Shi, Bowen, Wang, Xinyu, Lu, Qijue, Li, Chunguang, Chen, Hezhong   +6 more
openaire   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

MOESM1 of Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-ι and TGF-β

, 2018
Additional file 1. Minimum Standards of Reporting Checklist.
Huang, Chengliang, Wu, Xu, Wang, Shengpeng, Wang, Wenjun, Guo, Fang, Chen, Yuanyuan, Pan, Bi, Zhang, Ming, Fan, Xianming   +8 more
openaire   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Latent-TGF-β has a domain swapped architecture

Nature Communications
The multifunctional cytokine TGF-β is a dimeric protein produced within a latent complex (L-TGF-β). Latency is maintained by disulfide linked homodimeric prodomains forming a ring encircling the non-covalently bound mature TGF-β homodimer.
Mingliang Jin, Robert I. Seed, Tiffany Shing, Li Wang, Junrui Li, Yifan Cheng, Stephen L. Nishimura   +6 more
doaj   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

MOESM3 of Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method

, 2018
Additional file 3. Demographics and clinical characteristics of TCGA HNSCC cohort.
Huang, Teng, Huang, Wei, Lu, Hong, Zhang, Bi-yun, Ma, Jun, Zhao, Di, Wang, Yi-jun, Yu, Da-hai, He, Xia   +8 more
openaire   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source

Recent advances in therapeutic use of transforming growth factor-beta inhibitors in cancer and fibrosis

Frontiers in Oncology
Transforming growth factor-beta (TGF-β) has long been known to be associated with early embryonic development and organogenesis, immune supervision, and tissue repair and homeostasis in adults.
Hanhui Jing, Yan Gao, Linyuan Jing, Hanyu Yang, Shanglong Liu   +4 more
doaj   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source