Results 1 to 10 of about 418,971 (241)
Latent-TGF-β has a domain swapped architecture [PDF]
Nature CommunicationsThe multifunctional cytokine TGF-β is a dimeric protein produced within a latent complex (L-TGF-β). Latency is maintained by disulfide linked homodimeric prodomains forming a ring encircling the non-covalently bound mature TGF-β homodimer.
Mingliang Jin +6 more
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Unraveling the influence of TGF-β rs9282871 and miRNA let-7c relative expression on TGF-β production in hepatocellular carcinoma patients [PDF]
Journal of Genetic Engineering and BiotechnologyHepatocellular carcinoma (HCC) is ranked globally as the second most common cancer-related death. Transforming growth factor beta (TGF-β) plays a dual role in HCC.
Sally Farouk +3 more
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Frontiers in Bioengineering and Biotechnology, 2021 The application of amniotic membrane (AM) on chronic wounds has proven very effective at resetting wound healing, particularly in re-epithelialization. Historically, several aspects of AM effect on wound healing have been evaluated using cell models.
Catalina Ruiz-Cañada +5 more
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The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease
Cells, 2021 The Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver development and homeostasis and become a relevant factor involved in different liver pathologies, particularly fibrosis and cancer. The family of NADPH oxidases (NOXs) has
Macarena Herranz-Itúrbide +4 more
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Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma
Redox Biology, 2023 The NADPH oxidase NOX4 has been proposed as necessary for the apoptosis induced by the Transforming Growth Factor-beta (TGF-β) in hepatocytes and hepatocellular carcinoma (HCC) cells.
Rut Espinosa-Sotelo +17 more
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Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective
Cells, 2020 Chronic wounds are characterized for their incapacity to heal within an expected time frame. Potential mechanisms driving this impairment are poorly understood and current hypotheses point to the development of an unbalanced milieu of growth factor and ...
Sergio Liarte +2 more
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Cells, 2020 Defects in wound closure can be related to the failure of keratinocytes to re-epithelize. Potential mechanisms driving this impairment comprise unbalanced cytokine signaling, including Transforming Growth Factor-β (TFG-β).
Sergio Liarte +2 more
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NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice
Redox Biology, 2021 Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass.
M. Herranz-Itúrbide +11 more
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Frontiers in Endocrinology, 2023 Skin wound healing is a physiological process that involves several cell types. Among them, endothelial cells are required for inflammation resolution and neo‐angiogenesis, both necessary for tissue restoration after injury.
Javier Stelling-Férez +6 more
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SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
Communications Biology, 2022 In pancreatic ductal adenocarcinoma cells and patient tissue, SMAD2/3 is shown to mediate oncogenic effects of TGF-β in the absence of SMAD4.
Adrien Bertrand-Chapel +21 more
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