TGF-β-responsive CAR-T cells promote anti-tumor immune function. [PDF]
, 2018 A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF-β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T-cell stimulant.
Chang, ZeNan L +4 more
core +1 more source
MicroRNA-483 amelioration of experimental pulmonary hypertension. [PDF]
, 2020 Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit.
Bai, Liang +22 more
core +1 more source
Transforming growth factor-β: Biology and application to cancer therapy [PDF]
Archive of Oncology, 2009 Transforming growth factor-β (TGF-β), an extensively investigated cytokine, plays a very important role in promoting the spread of cancers in the body, and can play a direct role in facilitating metastasis.
Ivanović Vesna
doaj +1 more source
Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]
, 2018 The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M +3 more
core +2 more sources
Autocrine TGF-β Induces Epithelial to Mesenchymal Transition in Human Amniotic Epithelial Cells
Cell Transplantation, 2013 Human amniotic epithelial cells (hAECs) have been the object of intense research due to their potential therapeutic use. In this paper, we present molecular evidence of a bona fide epithelial to mesenchymal transition (EMT) undergone by hAECs.
Antonia Alcaraz +7 more
doaj +1 more source
Murine CD4 T cells produce a new form of TGF-β as measured by a newly developed TGF-β bioassay. [PDF]
PLoS ONE, 2011 It is generally assumed that T cells do not produce active TGF-β since active TGF-β as measured in supernatants by ELISA without acidification is usually not detectable. However, it is possible that active TGF-β from T cells may take a special form which
Takatoku Oida, Howard L Weiner
doaj +1 more source
Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]
, 2017 Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario +13 more
core +1 more source
Editorial Special Issue TGF-Beta/BMP Signaling Pathway
Cells, 2020 The transforming growth factor β (TGF-β) superfamily plays key roles in development and tissue homeostasis, controlling the maintenance and regeneration of mature tissues [...]
Isabel Fabregat +2 more
doaj +1 more source
Lumican promotes joint fibrosis through TGF‐β signaling
FEBS Open Bio, 2020 Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form fibrotic scar tissue and adhesions within joint capsules.
Dahai Xiao +8 more
doaj +1 more source
Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
Advanced Science, 2022 Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists.
Xiao Wang +11 more
doaj +1 more source