Results 1 to 10 of about 222,067 (306)
JAK3 as an emerging target for topical treatment of inflammatory skin diseases [PDF]
, 2016 The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia ...
Alves de Medeiros, Ana +5 more
core +9 more sources
Emerging roles of keratinocytes in nociceptive transduction and regulation
Frontiers in Molecular Neuroscience, 2022 Keratinocytes are the predominant block-building cells in the epidermis. Emerging evidence has elucidated the roles of keratinocytes in a wide range of pathophysiological processes including cutaneous nociception, pruritus, and inflammation ...
Xiaohan Xu +7 more
doaj +1 more source
Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions
Cells, 2021 Whilst the importance of keratinocytes as a first-line defense has been widely investigated, little is known about their interactions with non-resident immune cells.
Peter Seiringer +9 more
doaj +1 more source
Cells, 2023 Keratinocytes are one of the primary cells affected by psoriasis inflammation. Our study aimed to delve deeper into their morphology, transcriptome, and epigenome changes in response to psoriasis-like inflammation.
Ameneh Ghaffarinia +11 more
doaj +1 more source
CA: A Cancer Journal for Clinicians, 2003 Keratinocyte carcinoma is by far the most common cancer in the United States. Basal cell carcinomas and squamous cell carcinomas account for approximately 80% and 20% of cases of KC, respectively. The term nonmelanoma skin cancer is commonly used to refer to squamous cell carcinomas and basal cell carcinomas; however, other types of nonmelanoma skin ...
Michael R, Albert, Martin A, Weinstock
openaire +2 more sources
Cells, 2020 Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs). Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances.
Ophélie Pierre +8 more
doaj +1 more source
In Vitro Differentiation of Human Skin-Derived Cells into Functional Sensory Neurons-Like
Cells, 2020 Skin-derived precursor cells (SKPs) are neural crest stem cells that persist in certain adult tissues, particularly in the skin. They can generate a large type of cell in vitro, including neurons.
Adeline Bataille +12 more
doaj +1 more source
Revisiting oxytocin generation in keratinocytes
Biophysics and Physicobiology, 2023 Some evidence suggests that oxytocin, which is a neuropeptide conventionally thought to be synthesized in the hypothalamus and released by the posterior pituitary, is generated in peripheral keratinocytes, but the details are lacking and the mRNA ...
Kanta Fujimoto +3 more
doaj +1 more source
Protein & Cell, 2017 Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema.
Olivier Gouin +10 more
doaj +1 more source
Immunohistochemical and histochemical analysis of the rat skin after local electron irradiation
Open Veterinary Journal, 2023 Background: Skin cancer is the most frequently diagnosed type of cancer among all malignant neoplasms. The decrease in mitotic activity and the death of intact keratinocytes arise due to the constantly renewing epithelium is highly sensitive to ionising
Grigory Demyashkin +9 more
doaj +1 more source