Results 1 to 10 of about 110,363 (120)
Purple Corn Silk Extract Attenuates UVB-Induced Inflammation in Human Keratinocyte Cells
Scientia Pharmaceutica, 2022 UVB is a causative factor for severe skin damage, such as cell aging, death, and inflammation. UVB easily permeates into the epidermis layer of human skin, which is mainly composed of keratinocyte cells.
Watcharaporn Poorahong +3 more
doaj +1 more source
Cell Death Discovery, 2022 Keratinocyte necroptosis (with proinflammatory characteristic) is required for epidermal damage in contact hypersensitivity (CHS). In DNCB-induced CHS mice model, we observed the aggravated keratinocyte death and increased phosphorylation level of MLKL ...
Ni Lian +12 more
doaj +1 more source
Frontiers in Immunology, 2021 Matrix stiffness, a critical physical property of the cellular environment, is implicated in epidermal homeostasis. In particular, matrix stiffening during the pathological progression of skin diseases appears to contribute to cellular responses of ...
Hyewon Chung +8 more
doaj +1 more source
Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. [PDF]
PLoS ONE, 2009 The human epidermis is comprised of several layers of specialized epithelial cells called keratinocytes. Normal homoeostasis of the epidermis requires that the balance between keratinocyte proliferation and terminal differentiation be tightly regulated ...
Frances E Lock, Neil A Hotchin
doaj +1 more source
Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis
Frontiers in Immunology, 2022 Transient receptor potential melastatin 4 (TRPM4) is a Ca2+-activated, monovalent cation channel that is expressed in a wide range of cells. We previously reported two gain-of-function (GoF) mutations of TRPM4 as the cause of progressive symmetric ...
Daisuke Yamada +8 more
doaj +1 more source
Usefulness of Kaloderm® in Finger Tip Necrosis : A Case Report [PDF]
Kosin Medical Journal, 2021 We experienced a case of crush injury of the hand for which we performed a flap surgery and treated the necrotic parts placement using cultured allogeneic keratinocytes (Kaloderm®) with good results.
Chung-Min Yoon +2 more
doaj +1 more source
Nature Communications, 2023 The role of keratinocyte subpopulations in the different phases of the viral cycle during HPV16 infection remains to be characterised. Here, single cell RNA sequencing of HPV16 infected and uninfected organoids identifies 12 distinct keratinocyte ...
Mary C. Bedard +33 more
doaj +1 more source
Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus
Frontiers in Immunology, 2021 Dry skin is a symptom of skin barrier dysfunction that evokes pruritus; however, the cutaneous neuroimmune interactions underlying dry skin-induced pruritus remain unclear.
Wook-Joo Lee +3 more
doaj +1 more source
Frontiers in Immunology, 2022 The epidermis, outermost layer of the skin, forms a barrier and is involved in innate and adaptive immunity in an organism. Keratinocytes participate in all these three protective processes.
Teruki Dainichi +20 more
doaj +1 more source
Impact of p53 Knockout on Protein Data Set of HaCaT Cells in Confluent and Subconfluent Conditions
Data, 2022 The immortalized keratinocytes, HaCaT, are a popular model for skin research (toxicity, irritation, allergic reactions, or interaction of cells). They maintain a stable keratinocyte phenotype and respond to keratinocyte differentiation stimuli.
Alexander L. Rusanov +7 more
doaj +1 more source