Results 41 to 50 of about 104,455 (266)

Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis

open access: yesJournal of Inflammation Research, 2022
Kaixuan Ren, Yumin Xia Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, People’s Republic of ChinaCorrespondence: Yumin Xia, Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong
Ren K, Xia Y
doaj  

Nitrogen mustard inhibits keratinocyte proliferation by activating AMPK/autophagy pathway

open access: yesDi-san junyi daxue xuebao, 2019
Objective To explore the role of AMP-activated protein kinase (AMPK)/ autophagy signaling pathway in nitrogen mustard (NM)-induced cytotoxicity in cultured keratinocytes.
DONG Xunhu   +4 more
doaj   +1 more source

Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes

open access: yesFrontiers in Cell and Developmental Biology, 2021
Mutations of H-Ras, a member of the RAS family, are preferentially found in cutaneous squamous cell carcinomas (SCCs). H-Ras has been reported to induce autophagy, which plays an essential role in tissue homeostasis in multiple types of cancer cells and ...
Shuangshuang Wang   +14 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha

open access: yesFrontiers in Molecular Biosciences, 2023
Retinol is widely used in topical skincare products to ameliorate skin aging and treat acne and wrinkles; however, retinol and its derivatives occasionally have adverse side effects, including the induction of irritant contact dermatitis.
Azusa Saika   +14 more
doaj   +1 more source

Role of autophagy during cutaneous wound healing in mice

open access: yesDi-san junyi daxue xuebao, 2019
Objective To observe the dynamic changes in autophagy during cutaneous wound healing and investigate its possible contributions to wound repair. Methods Two skin wound of 6 mm in size were inflicted on the back of GFP-LC3 transgenic mice.
ZHAO Na   +6 more
doaj   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

open access: yesAdvanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim   +7 more
wiley   +1 more source

Keratinocyte Binding Assay Identifies Anti-Desmosomal Pemphigus Antibodies Where Other Tests Are Negative

open access: yesFrontiers in Immunology, 2018
The serological diagnosis of pemphigus relies on the detection of IgG autoantibodies directed against the epithelial cell surface by indirect immunofluorescence (IIF) on monkey esophagus and against desmoglein 1 (Dsg1) and Dsg3 by ELISA.
Federica Giurdanella   +4 more
doaj   +1 more source

Adverse Effect of Blue Light on DNA Integrity Is Accelerated by 5-Aminolevulinic Acid in HaCaT Human Keratinocyte Cells and B16F1 Murine Melanoma Cells

open access: yesBiology, 2022
Several studies have suggested the potential benefits of 5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT). 5-ALA is a precursor of heme, which generates reactive oxygen species (ROS) following photoirradiation.
Taiki Sato, Kazuomi Sato
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

open access: yesAdvanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best   +5 more
wiley   +1 more source

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