Results 31 to 40 of about 137,265 (305)

Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders

Frontiers in Immunology, 2020
Background/Objective: Skin fibrosis is the result of aberrant processes leading to abnormal deposition of extracellular matrix (ECM) in the dermis. In healthy skin, keratinocytes participate to maintain skin homeostasis by actively crosstalking with ...
Barbara Russo, Nicolò C. Brembilla, Nicolò C. Brembilla, Carlo Chizzolini   +3 more
doaj   +1 more source

The Protective Effect of Hamamelis virginiana Stem and Leaf Extract on Fine Dust-Induced Damage on Human Keratinocytes

Cosmetics, 2021
Witch hazel extracts have been used for decades as cosmetic ingredients in skin care products. Our present study aims to evaluate its potential in anti-pollution products using a previously reported in vitro model. Calcium is a universal second messenger,
Jiyoung Choi, Dongki Yang, Mi Yeon Moon, Gi Yeon Han, Moon Sik Chang, Joonseok Cha   +5 more
doaj   +1 more source

Individual Keratinocyte Necroses in the Epidermis Are Apoptotic Keratinocytes in the Skin

Diagnostics, 2023
The patient was a 44-year-old woman with Stevens–Johnson syndrome due to receiving Baktar® (sulfamethoxazole trimethoprim) medication at our outpatient dermatology clinic. The epidermis, dermis, and subcutaneous adipose tissue samples showed numerous necrotic keratinocytes in the epidermis.
Mitsuhiro Tachibana, Hideki Hamayasu, Kazuki Tomita, Yuta Kage   +3 more
openaire   +3 more sources

Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

eLife, 2020
The intermediate filament protein keratin 14 (K14) provides vital structural support in basal keratinocytes of epidermis. Recent studies evidenced a role for K14-dependent disulfide bonding in the organization and dynamics of keratin IFs in skin ...
Yajuan Guo, Catherine J Redmond, Krystynne A Leacock, Margarita V Brovkina, Suyun Ji, Vinod Jaskula-Ranga, Pierre A Coulombe   +6 more
doaj   +1 more source

Developing methods of measuring and manipulating melanocyte/keratinocyte ratios to inform potential treatment of vitiligo vulgaris [PDF]

, 2020
Introduction My doctoral work focuses on the disease vitiligo vulgaris. Several treatments already exist however, one totally successful remedy is unavailable.
Shetty, N.
core  

Keratinocyte Growth Factor Promotes Melanosome Transfer to Keratinocytes [PDF]

Journal of Investigative Dermatology, 2005
Melanogenesis and melanosome transfer from the melanocytes to the neighboring keratinocytes are induced by ultraviolet radiation and modulated by autocrine and paracrine factors. Keratinocyte growth factor (KGF/fibroblast growth factor (FGF)7) is a paracrine mediator of human keratinocyte growth and differentiation. We evaluated the influence of KGF on
CARDINALI G, CECCARELLI, SIMONA, KOVACS D, ASPITE N, LOTTI, Lavinia Vittoria, TORRISI, Maria Rosaria, PICARDO M.   +6 more
openaire   +4 more sources

GJB4 variants linked to skin disease exhibit a trafficking deficiency en route to gap junction formation that can be restored by co-expression of select connexins

Frontiers in Cell and Developmental Biology, 2023
Epidermal keratinocytes are enriched with at least nine connexins that are key regulators of epidermal homeostasis. The role of Cx30.3 in keratinocytes and epidermal health became evident when fourteen autosomal dominant mutations in the Cx30.3-encoding ...
Sergiu A. Lucaciu, Sergiu A. Lucaciu, Rhett Figliuzzi, Ruth Neumann, Samina Nazarali, Luigi Del Sordo, Luigi Del Sordo, Stephanie E. Leighton, Alexandra Hauser, Qing Shao, Danielle Johnston, Donglin Bai, Dale W. Laird, Dale W. Laird   +13 more
doaj   +1 more source

The keratinocyte in epidermal renewal and defence

, 2009
Traditionally, keratinocytes have been considered inert constituents of the multilayered epidermis. Today's understanding has fundamentally changed. The keratinocyte is now recognized as an active player in epidermal renewal with key functions in the ...
Muller, E.J., Suter, M.M., Welle, M., Wilhelmina Bergman, Schulze, K., Eliane J. Müller, Roosje, P., Petra Roosje, Katja Schulze, Maja M. Suter, Monika Welle, Bergman, W., Bergmann, Wilhelmina, Müller EJ, Welle, Monika Maria, Roosje P, Bergman W, Suter MM, Müller, Eliane Jasmine, Roosje Hasler, Pieternella, Welle M, Schulze K   +21 more
core   +1 more source

YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

Life, 2022
The Hippo-YAP pathway serves as a central signalling hub in epithelial tissue generation and homeostasis. Yes-associated protein (YAP) is an essential downstream transcription cofactor of this pathway, with its activity being negatively regulated by ...
Yunying Huang, Usama Sharif Ahmad, Ambreen Rehman, Jutamas Uttagomol, Hong Wan   +4 more
doaj   +1 more source

Lipocalin 2 Participates in the Epidermal Differentiation and Inflammatory Processes of Psoriasis

Journal of Inflammation Research, 2022
Kaixuan Ren, Yumin Xia Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710004, People’s Republic of ChinaCorrespondence: Yumin Xia, Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong
Ren K, Xia Y
doaj