Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines [PDF]
, 2000 In order to investigate the correlations between constitutive proteinase expression and the degree of tumorigenicity of cancer cells we have studied a model system of three keratinocyte cell lines.
Fink, E. +9 more
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Keratinocyte-restricted deletion of α-pv results in progressive and persistent hair loss.
, 2020 (A) Tail-skin of 8-week-old (would-mount) and back-skin of 2-week-old (paraffin section) control and α-pvΔK mice stained for α-pv and α6 integrin. Scale bars are 40 μm and 20 μm, respectively.
Johannes Altstätter (107214) +3 more
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Keratinocyte Cancer Mortality in Kidney Transplant Recipients
, 2021 BACKGROUND: Kidney transplant recipients are at increased risk of developing and dying from keratinocyte cancer. Risk factors for keratinocyte cancer death have not been previously described.METHODS: In a cohort of kidney transplant recipients ...
Shao, Emily Ximin +16 more
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Stratum basale keratinocyte expression of the cell-surface glycoprotein CDCP1 during epidermogenesis and its role in keratinocyte migration [PDF]
, 2013 Background Epidermogenesis and epidermal wound healing are tightly regulated processes during which keratinocytes must migrate, proliferate and differentiate. Cell-to-cell adhesion is crucial to the initiation and regulation of these processes.
Manton, K. J. +15 more
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Anti-Atopic Dermatitis Activity of Epi-Oxyzoanthamine Isolated from Zoanthid
Marine Drugs, 2023 Atopic dermatitis (AD, eczema) is a condition that causes dry, itchy, and inflamed skin and occurs most frequently in children but also affects adults. However, common clinical treatments provide limited relief and have some side effects.
Chieh-Chen Huang +8 more
doaj +1 more source
Seeing Keratinocyte Proteins through the Looking Glass of Intrinsic Disorder
, 2021 Epidermal keratinocyte proteins include many with an eccentric amino acid content (compositional bias), atypical ultrastructural fate (built-in protease sensitivity), or assembly visible at the light microscope level (cytoplasmic granules). However, when
Brian J. Aneskievich +2 more
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Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
Exploration of Immunology, 2021 Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2).
Masutaka Furue, Mihoko Furue
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Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins. [PDF]
, 2023 Small proline-rich proteins (SPRRPs) are traditionally known for their function in keratinocyte homeostasis. Recent evidence demonstrates their involvement in additional diverse physiological processes ranging from p53 signaling and direct prevention of ...
Zabini, Adam +2 more
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Keratinocyte PIEZO1 modulates cutaneous mechanosensation
eLife, 2022 Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the
Alexander R Mikesell +5 more
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Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis [PDF]
, 2009 Vitiligo is a skin disorder characterized by loss of functional melanocytes. Keratinocytes contribute to melanocyte homeostasis, and keratinocyte alteration may play a role in melanocyte dysfunction in vitiligo.
Massi, Daniela +24 more
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