Results 11 to 20 of about 164,326 (306)
Frontiers in Immunology, 2022 The epidermis, outermost layer of the skin, forms a barrier and is involved in innate and adaptive immunity in an organism. Keratinocytes participate in all these three protective processes.
Teruki Dainichi +20 more
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Impact of p53 Knockout on Protein Data Set of HaCaT Cells in Confluent and Subconfluent Conditions
Data, 2022 The immortalized keratinocytes, HaCaT, are a popular model for skin research (toxicity, irritation, allergic reactions, or interaction of cells). They maintain a stable keratinocyte phenotype and respond to keratinocyte differentiation stimuli.
Alexander L. Rusanov +7 more
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Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential
Frontiers in Cell and Developmental Biology, 2021 The skin is the biggest organ and provides a physical and immunological barrier against pathogen infection. The distribution of primary cilia in the skin of mice has been reported, but which cells in human skin have them has not, and we still know very ...
Manami Toriyama +5 more
doaj +1 more source
Role of FGFR2b expression and signaling in keratinocyte differentiation. Sequential involvement of PKCδ and PKCα [PDF]
, 2018 The tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular ...
Belleudi, Francesca +4 more
core +2 more sources
Active regulation of the epidermal calcium profile [PDF]
, 2012 A distinct calcium profile is strongly implicated in regulating the multi-layered structure of the epidermis. However, the mechanisms that govern the regulation of this calcium profile are currently unclear.
Adams, Matthew +2 more
core +2 more sources
Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema
BMC Pulmonary Medicine, 2005 Background Hepatocyte and keratinocyte growth factors are key growth factors in the process of alveolar repair. We hypothesized that excessive alveolar destruction observed in lung emphysema involves impaired expression of hepatocyte and keratinocyte ...
Marchal Joëlle +8 more
doaj +1 more source
Acta Dermato-Venereologica, 2020 Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the
Junqin Li +13 more
doaj +1 more source
Frontiers in Immunology, 2021 Rosacea is a common chronic inflammatory condition that mainly affects the central face. However, the molecular background of the normal central face and the transcriptional profiling and immune cell composition of rosacea lesions remain largely unknown.
Zhili Deng +41 more
doaj +1 more source
Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]
, 2018 The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker +43 more
core +1 more source
Matrix metalloproteinases-2,-3,-7,-9 and-10, but not MMP-11, are differentially expressed in normal, benign tumorigenic and malignant human keratinocyte cell lines [PDF]
, 2000 In order to investigate the correlations between constitutive proteinase expression and the degree of tumorigenicity of cancer cells we have studied a model system of three keratinocyte cell lines.
Bachmeier, B. E. +4 more
core +1 more source