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Tuberous sclerosis complex (TSC) is an autosomal dominant hereditary disease with hamartomatous growths in multiple organs due to loss-of-function variants in TSC1 or TSC2. In approximately 15% of patients with clinical TSC, no pathogenic variant can be
Eckart Haneke Eckart Haneke
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The Epidermis as an Adjuvant [PDF]
It is now clear that the epidermis has an active role in local immune responses in the skin. Keratinocytes are involved early in inflammation by providing first-line innate mechanisms and, in addition, can contribute to adaptive immune responses that may be associated with clinical disease.
Gutowska-Owsiak, D, Ogg, G
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A eudicot MIXTA family ancestor likely functioned in both conical cells and trichomes
The MIXTA family of MYB transcription factors modulate the development of diverse epidermal features in land plants. This study investigates the evolutionary history and function of the MIXTA gene family in the early-diverging eudicot model lineage ...
Simra Zahid +2 more
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1993). Since undifferentiated keratinocytes (i.e. basal cells) provide the major supply of catecholamines to the total epidermis, it seems feasible that those basal cells in contact with melanocytes are of major importance in signal transduction, metabolism, growth and differentiation.
K U, Schallreuter, J M, Wood
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3D CULTURE OF HaCaT KERATINOCYTE CELL LINE AS AN in vitro TOXICITY MODEL
Ex vivo dermal toxicology analyses are crucial for replacement of in vivo test methods and have been of interest in recent years for testing cosmetics, drugs, and chemicals.
Fikrettin Şahin +9 more
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Leaves have evolved to effectively harvest light, and, in parallel, to balance photosynthetic CO2 assimilation with water losses. At times, leaves must operate under light limiting conditions while at other instances (temporally distant or even within ...
George Karabourniotis +3 more
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IDENTIFICAÇÃO DE PEDÍCULO(S) NO TRATAMENTO DE QUISTO MUCOSO DIGITAL
Introdução: O quisto mucoso digital é uma lesão relativamente comum sendo a sua etiopatogenia controversa. Inicialmente admitia-se ser mucinose cutânea primária, resultante de processo degenerativo, sem relação com a articulação adjacente.
João Alves, Hugo Barreiros
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Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex.
Tanya L Brown +9 more
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The skin functions as a barrier protecting the body from dehydration and environmental insults. This barrier function is mainly provided by the outermost layer of the skin, the epidermis. The epidermis is maintained by epidermal stem cells which reside in the basal layer and which generate daughter cells that move upward toward the surface of the skin.
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The structure of the ovary epidermis emitting odorous compounds in Allium karataviense Regel
Many plants develop in the petal epidermis papillae emitting essential oils. In species of the genus Allium, papillae occur in the ovary epidermis. The aim of this study was to determine the structure of papillae in Allium karataviense Regel and to ...
Beata Żuraw +3 more
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