Results 11 to 20 of about 167,203 (256)

Cortisol synthesis by primary human keratinocytes [PDF]

, 2009
PhDCortisol analogues have been used to treat skin disorders, such as psoriasis and atopic dermatitis, for over 50 years but the ability of normal human keratinocytes to synthesise cortisol has not been reported.
Hannen, Rosalind Francesca
core   +4 more sources

Emerging roles of keratinocytes in nociceptive transduction and regulation

Frontiers in Molecular Neuroscience, 2022
Keratinocytes are the predominant block-building cells in the epidermis. Emerging evidence has elucidated the roles of keratinocytes in a wide range of pathophysiological processes including cutaneous nociception, pruritus, and inflammation ...
Xiaohan Xu, Catherine Yu, Catherine Yu, Catherine Yu, Li Xu, Jijun Xu, Jijun Xu, Jijun Xu   +7 more
doaj   +1 more source

Unraveling Transcriptome Profile, Epigenetic Dynamics, and Morphological Changes in Psoriasis-like Keratinocytes: “Insights into Similarity with Psoriatic Lesional Epidermis”

Cells, 2023
Keratinocytes are one of the primary cells affected by psoriasis inflammation. Our study aimed to delve deeper into their morphology, transcriptome, and epigenome changes in response to psoriasis-like inflammation.
Ameneh Ghaffarinia, Szilárd Póliska, Ferhan Ayaydin, Aniko Goblos, Shahram Parvaneh, Máté Manczinger, Fanni Balogh, Lilla Erdei, Zoltán Veréb, Kornélia Szabó, Zsuzsanna Bata-Csörgő, Lajos Kemény   +11 more
doaj   +1 more source

Keratinocytes Regulate the Threshold of Inflammation by Inhibiting T Cell Effector Functions

Cells, 2021
Whilst the importance of keratinocytes as a first-line defense has been widely investigated, little is known about their interactions with non-resident immune cells.
Peter Seiringer, Stefanie Eyerich, Kilian Eyerich, Daniela Dittlein, Anna Caroline Pilz, Emanuele Scala, Johannes Ring, Heidrun Behrendt, Andrea Cavani, Claudia Traidl-Hoffmann   +9 more
doaj   +1 more source

Characterisation of apoptotic responses in human keratinocytes expressnig alpha-6 integrin and CD44 [PDF]

, 2010
PhDa6 integrin has previously been proposed as a human keratinocyte stem cell markers. CD44-positive cells in epithelial tumours have been identified as potential cancer stem cells (CSCs) and display increased survival following chemotherapy ...
Wray, Helen
core   +4 more sources

Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling

Cells, 2020
Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs). Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances.
Ophélie Pierre, Maxime Fouchard, Paul Buscaglia, Nelig Le Goux, Raphaël Leschiera, Olivier Mignen, Joachim W. Fluhr, Laurent Misery, Raphaële Le Garrec   +8 more
doaj   +1 more source

In Vitro Differentiation of Human Skin-Derived Cells into Functional Sensory Neurons-Like

Cells, 2020
Skin-derived precursor cells (SKPs) are neural crest stem cells that persist in certain adult tissues, particularly in the skin. They can generate a large type of cell in vitro, including neurons.
Adeline Bataille, Raphael Leschiera, Killian L’Hérondelle, Jean-Pierre Pennec, Nelig Le Goux, Olivier Mignen, Mehdi Sakka, Emmanuelle Plée-Gautier, Cecilia Brun, Thierry Oddos, Jean-Luc Carré, Laurent Misery, Nicolas Lebonvallet   +12 more
doaj   +1 more source

Revisiting oxytocin generation in keratinocytes

Biophysics and Physicobiology, 2023
Some evidence suggests that oxytocin, which is a neuropeptide conventionally thought to be synthesized in the hypothalamus and released by the posterior pituitary, is generated in peripheral keratinocytes, but the details are lacking and the mRNA ...
Kanta Fujimoto, Kosuke Inada, Kotaro Oka, Etsuro Ito   +3 more
doaj   +1 more source

TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization

Protein & Cell, 2017
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema.
Olivier Gouin, Killian L’Herondelle, Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Mehdi Sakka, Virginie Buhé, Emmanuelle Plée-Gautier, Jean-Luc Carré, Luc Lefeuvre, Laurent Misery, Raphaele Le Garrec   +10 more
doaj   +1 more source

Chitin modulates innate immune responses of keratinocytes. [PDF]

, 2011
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian, Koller, Barbara, Thomas Ruzicka, Korting Hans Christian, Rupec Rudolph, Müller-Wiefel Alisa Sophie, Alisa Sophie Müller-Wiefel, Müller-Wiefel, Alisa Sophie, Rudolph Rupec, Koller Barbara, Hans Christian Korting, Ruzicka, Thomas, Barbara Koller, Ruzicka Thomas, Rupec, Rudolph   +14 more
core   +2 more sources