Results 41 to 50 of about 167,203 (256)

Protective effect of Saussurea involucrata polysaccharide against skin dryness induced by ultraviolet radiation

Frontiers in Pharmacology, 2023
Background: Exposure to ultraviolet B (UVB) radiation can damage the epidermis barrier function and eventually result in skin dryness. At present, little work is being devoted to skin dryness.
Lusheng Wang, Kaiye Yang, Rongrong Jing, Wengang Zhao, Keke Guo, Zhenlin Hu, Guangrong Liu, Nuo Xu, Jungang Zhao, Li Lin, Shuang Gao   +10 more
doaj   +1 more source

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]

, 2009
Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah, Ulrich Zügel, Thomas Ruzicka, Büchau Amanda, Dombrowski, Yvonne, Zügel, Ulrich, Steinmeyer, Andreas, Jürgen Schauber, Schauber, Jürgen, Büchau, Amanda, Sarah Koglin, Steinmeyer Andreas, Bradac, Eva, Mark Peric, Schauber Jürgen, Koglin Sarah, Amanda Büchau, Zügel Ulrich, Yvonne Dombrowski, Eva Bradac, Katrin Gross, Peric Mark, Gross, Katrin, Dombrowski Yvonne, Peric, Mark, Andreas Steinmeyer, Dombrowski, Yvonne; id_orcid, Bradac Eva, Groß Katrin, Ruzicka, Thomas, Ruzicka Thomas   +30 more
core   +2 more sources

Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis

Mediators of Inflammation, 2019
The interaction between tumor necrosis factor- (TNF-) like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducible 14 (Fn14) regulates the fate of keratinocytes, depending on the relative expression of TNF receptor (TNFR) 1 or TNFR2 ...
Xuening Wang, Dan Cheng, Guanglei Hu, Lili Liang, Fei Tan, Tong Xiao, Shengxiang Xiao, Yumin Xia   +7 more
doaj   +1 more source

Induction of autophagy improves skin and hair conditions in dogs with underlying diseases

Frontiers in Veterinary Science, 2023
BackgroundAutophagy was reported to play a crucial role in maintaining general and skin health.MethodsThe study used a synthesized autophagy inducer (AI) (Aquatide™ cospharm Inc.; Daejeon, Korea), for evaluating the effects of autophagy on skin and hair ...
Yoonji Kim, Yoonji Kim, Seung-Hwa Lee, Yunji Song, Yunji Song, Sekyoo Jeong, Ha-Jung Kim, Ha-Jung Kim   +7 more
doaj   +1 more source

MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting CTR9

European Journal of Histochemistry, 2022
Psoriasis is a chronic inflammatory skin disease. Although miRNAs are reported to be associated with the pathogenesis of psoriasis, the contribution of individual microRNAs toward psoriasis remains unclear. The miR-17-92 cluster regulates cell growth and
Qingwen Li, Jiao Zhang, Shougang Liu, Fangfei Zhang, Jiayi Zhuang, Yongfeng Chen   +5 more
doaj   +1 more source

Expression and Functional Studies on the Noncoding RNA, PRINS. [PDF]

, 2012
PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated
Széll Márta, Kemény Lajos, Dobozy Attila, Csörgő Sándorné Bata Zsuzsanna, Bacsa, Sarolta, Dobozy, Attila, Szegedi, Krisztina, Antal, Mária, István Németh, Krisztina Szegedi, Bacsa Sarolta, Lajos Kemény, Mária Antal, Göblös, Anikó, Széll, Márta, Sarolta Bacsa, Attila Dobozy, Németh István Balázs, Csörgő-Bata, Zsuzsanna, Anikó Göblös, Göblös Anikó, Németh, István Balázs, Márta Széll, Szegedi Krisztina, Kemény, Lajos, Antal Mária, Zsuzsanna Bata-Csörgő   +26 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Epidermis in Microgravity and Unloading Conditions and Their Effects on Wound Healing

Frontiers in Bioengineering and Biotechnology, 2022
The future objectives of human space flight are changing from low-term permanence in the International Space Station to missions beyond low Earth orbit to explore other planets.
Stefano Bacci, Stefano Bacci, Daniele Bani, Daniele Bani   +3 more
doaj   +1 more source