Results 51 to 60 of about 167,203 (256)
MCP-1 mRNA Expression in Basal Keratinocytes of Psoriatic Lesions [PDF]
, 1993 In addition to hyperproliferation of keratinocytes, psoriasis is characterized by pronounced leukocytic infiltration. In contrast to the epidermal localization of neutrophils and T lymphocytes, macrophages are almost exclusively restricted to the dermal ...
Müller, Christoph +15 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Cutaneous lupus erythematosus: insights from molecular pathogenesis to targeted therapies [PDF]
Exploration of ImmunologyCutaneous lupus erythematosus (CLE) is the most common organ manifestation in individuals diagnosed with systemic lupus erythematosus (SLE). CLE can occur either alone or in association with SLE; in the latter case, it substantially increases the ...
Fatima K. Alduraibi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Calreticulin: a multifunctional protein with potential therapeutic applications for chronic wounds
Frontiers in Medicine, 2023 Calreticulin is recognized as a multifunctional protein that serves an essential role in diverse biological processes that include wound healing, modification and folding of proteins, regulation of the secretory pathway, cell motility, cellular ...
Andrew P. Sawaya +8 more
doaj +1 more source
Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes [PDF]
, 2009 DNA oligonucleotides (ODN) applied to an organism are known to modulate the innate and adaptive immune system. Previous studies showed that a CpG-containing ODN (CpG-1-PTO) and interestingly, also a non-CpG-containing ODN (nCpG- 5-PTO) suppress ...
Annette Dorn +19 more
core +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Immune evasion during varicella zoster virus infection of keratinocytes
, 2009 Summary T cells are sensitized during varicella-zoster virus (VZV) infection and are important for control of viral spread and reactivation.
Malavige, G.N. +3 more
core +2 more sources
Might Necrotic Keratinocytes Contribute to the Diagnosis and Pathogenesis of Psoriasis?
Dermatology Practical & ConceptualIntroduction: Psoriasis is a chronic inflammatory skin disease that can pose challenges in histopathological diagnosis. The diagnostic importance of necrotic keratinocytes has recently been emphasized.
Bengu Cevirgen Cemil +3 more
doaj +1 more source
Keratinocytes from human skin respond as typical immune cells after the stimulation with _Trichophyton rubrum_ [PDF]
, 2007 _Trichophyton rubrum_ is the main agent causing dermatophytosis (1). Keratinocytes are considered to be the first physical barrier of defense against pathogens (2). But not only a physical barrier.
Luz A. García-Madrid +1 more
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