Results 51 to 60 of about 163,612 (298)
The Epidermis in Microgravity and Unloading Conditions and Their Effects on Wound Healing
Frontiers in Bioengineering and Biotechnology, 2022 The future objectives of human space flight are changing from low-term permanence in the International Space Station to missions beyond low Earth orbit to explore other planets.
Stefano Bacci +3 more
doaj +1 more source
Keratinocytes as initiators of inflammation [PDF]
The Lancet, 1991 Environmental stimuli responsible for inducing cutaneous inflammation include contact allergens and ultraviolet light. We postulate that these diverse stimuli trigger a cutaneous inflammatory response by directly inducing epidermal keratinocytes to elaborate specific pro-inflammatory cytokines and adhesion molecules.
J.N.W.N Barker +5 more
openaire +3 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The role of GLI2 in human basal cell carcinoma tumourigenesis [PDF]
, 2010 PhDAbnormal Sonic Hedgehog (SHH) signalling leads to increased transcriptional activation of its downstream effector, GLI2, which is implicated in the pathogenesis of a variety of human tumours, including human basal cell carcinoma (BCC).
Pantazi, Eleni
core +4 more sources
Might Necrotic Keratinocytes Contribute to the Diagnosis and Pathogenesis of Psoriasis?
Dermatology Practical & ConceptualIntroduction: Psoriasis is a chronic inflammatory skin disease that can pose challenges in histopathological diagnosis. The diagnostic importance of necrotic keratinocytes has recently been emphasized.
Bengu Cevirgen Cemil +3 more
doaj +1 more source
Cutaneous lupus erythematosus: insights from molecular pathogenesis to targeted therapies [PDF]
Exploration of ImmunologyCutaneous lupus erythematosus (CLE) is the most common organ manifestation in individuals diagnosed with systemic lupus erythematosus (SLE). CLE can occur either alone or in association with SLE; in the latter case, it substantially increases the ...
Fatima K. Alduraibi +2 more
doaj +1 more source
Keratinocytes in Skin Disorders: The Importance of Keratinocytes as a Barrier
, 2022 Keratinocytes are the major structural component of the epidermis. They differentiate from the basal through spinous to granular layers, and abrupt loss of nucleus pushes them to differentiate into cornified layers, which exfoliates as scales. Differentiation process is tightly controlled by the organized expression of transcription factors and other ...
Mayumi Komine +9 more
openaire +1 more source
IL-27 regulates IL-18 binding protein in skin resident cells [PDF]
, 2012 IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased ...
Wittmann, M +23 more
core +2 more sources
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Calreticulin: a multifunctional protein with potential therapeutic applications for chronic wounds
Frontiers in Medicine, 2023 Calreticulin is recognized as a multifunctional protein that serves an essential role in diverse biological processes that include wound healing, modification and folding of proteins, regulation of the secretory pathway, cell motility, cellular ...
Andrew P. Sawaya +8 more
doaj +1 more source