Functional characterization of cultured keratinocytes after acute cutaneous burn injury. [PDF]
, 2012 In addition to forming the epithelial barrier against the outside environment keratinocytes are immunologically active cells. In the treatment of severely burned skin, cryoconserved keratinocyte allografts gain in importance.
Gerd G Gauglitz +17 more
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Mammalian Epidermis: A Compendium of Lipid Functionality
Frontiers in Physiology, 2022 Mammalian epidermis is a striking example of the role of lipids in tissue biology. In this stratified epithelium, highly specialized structures are formed that leverage the hydrophobic properties of lipids to form an impermeable barrier and protect the ...
Matteo Vietri Rudan, Fiona M. Watt
doaj +1 more source
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt [PDF]
, 2004 The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated by FOXN1 are unknown.
Ofstad, T.A. +14 more
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EpCAM Induction Functionally Links to the Wnt-Enhanced Cell Proliferation in Human Keratinocytes
Cell Transplantation, 2014 Accelerating proliferation of primary keratinocytes benefits skin autografts for severely burned patients. Wnt signal, a conserved pathway controlling cell cycle and morphogenesis in embryo, also involves in cell proliferation and tumorigenesis in adult ...
Ching-I Shen +7 more
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Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin [PDF]
, 1996 The cornified envelope is a layer of transglutaminase cross-linked protein that is deposited under the plasma membrane of keratinocytes in the outermost layers of the epidermis.
Dooley, TP +9 more
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International Journal of Dentistry, 2011 Potentially malignant oral leukoplakias arise within precancerized epithelial fields consisting of cytogenetically altered keratinocytes at various stages of transformation.
L. Feller, J. Lemmer
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Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation
Frontiers in Immunology, 2023 IntroductionChronic inflammatory skin diseases may have a profound negative impact on the quality of life. Current treatment options may be inadequate, offering an unsatisfactory response or side effects.
Hakim Ben Abdallah +6 more
doaj +1 more source
Two mechanisms regulate keratin K15 expression in keratinocytes:role of PKC/AP-1 and FOXM1 mediated signalling [PDF]
, 2012 Background: Keratin 15 (K15) is a type I keratin that is used as a marker of stem cells. Its expression is restricted to the basal layer of stratified epithelia, and the bulge in hair follicles.
Ahmad Waseem (155362) +30 more
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Korean red ginseng extracts alleviate skin damage in heat-stimulated skin cells by suppressing NF-κB activation [PDF]
Archives of Biological SciencesThis study explored the impact of heat stimulation on skin barrier damage, aging, and inflammatory responses by analyzing gene and protein-level changes.
Kim Jeeyoung +4 more
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Frontiers in Medicine, 2023 BackgroundThe incidence of diabetes-related wounds is widespread, and the treatment is challenging. We found that Moist Exposed Burn Ointment (MEBO) promotes the healing of diabetes-related wounds, but the mechanism is not clear.MethodsThis study aimed ...
Yuanxun Gong +6 more
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