Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1 [PDF]
, 2018 Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is downregulated in prostate cancer and upregulated in the stroma in benign prostatic ...
A Dutta +65 more
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Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
Frontiers in Oncology, 2018 The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of different cellular processes that are essential for tissue and organ homeostasis.
Isabel Fabregat +4 more
doaj +1 more source
Cells, 2022 Nephronectin (NPNT) is an extracellular matrix protein in the glomerular basement membrane that is produced by podocytes and is important for the integrity of the glomerular filtration barrier. Upregulated transforming growth factor β (TGF-β) and altered
Nina Sopel +3 more
doaj +1 more source
Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer [PDF]
, 2016 Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered ...
A G Pockley +45 more
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Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart. [PDF]
PLoS ONE, 2011 BACKGROUND: Neuroendocrine activation and local mediators such as transforming growth factor-β₁ (TGF-β₁) contribute to the pathobiology of cardiac hypertrophy and failure, but the underlying mechanisms are incompletely understood.
Michael Huntgeburth +13 more
doaj +1 more source
TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy
Frontiers in Immunology, 2022 Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes, such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides, TGF-β plays a vital role in diseases, including cancer.
Ming Yi +6 more
doaj +1 more source
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. [PDF]
, 2014 Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif.
Anwar, Saba +5 more
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TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
core +2 more sources
Frontiers in Immunology, 2022 Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian development and disease, particularly cancer, has constantly been updated.
Baode Chen +4 more
doaj +1 more source
HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]
, 2015 The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone +6 more
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