Autophagy, TGF-beta and SMAD-2/3 signaling regulates interferon-beta response in respiratory syncytial virus infected macrophages [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 Human respiratory syncytial virus (RSV) is a lung tropic virus causing severe airway diseases including bronchiolitis and pneumonia among infants, children and immuno-compromised individuals.
Swechha Pokharel +2 more
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Identification of potential key genes of TGF-beta signaling associated with the immune response and prognosis of ovarian cancer based on bioinformatics analysis [PDF]
Heliyon, 2023 Background: TGF-beta signaling is a key regulator of immunity and multiple cellular behaviors in cancer. However, the prognostic and therapeutic role of TGF-beta signaling-related genes in ovarian cancer (OV) remains unexplored.
Xiaoxue Zhang +4 more
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Frontiers in Cell and Developmental Biology, 2020 Fibrosis is a common phenotype that often leads to the progression of blood pressure-induced chronic kidney disease (CKD). TGF-beta plays an important role in promoting pathogenesis, and NLRP3 is a critical mediator in the progression of blood pressure ...
Kaimin Zhang +10 more
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Effects of ultrasound on Transforming Growth Factor-beta genes in bone cells [PDF]
European Cells & Materials, 2005 Therapeutic ultrasound (US) is a widely used form of biophysical stimulation that is increasingly applied to promote fracture healing. Transforming growth factor-beta (TGF-beta), which is encoded by three related but different genes, is known to play a ...
J Harle, F Mayia, I Olsen, V Salih
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GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH [PDF]
Basrah Journal of Veterinary Research, 2020 Transforming growth factor-β1 (TGF-β1) is an important immune regulatorcritical for immune homeostasis. Accumulating evidence suggests that TGF-β1 has acrucial regulatory role in CNS development and potential implications forneurogenesis ...
Khulood, Abdulrazaq Kaleel +1 more
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TGF-beta signal transduction: biology, function and therapy for diseases [PDF]
Molecular Biomedicine, 2022 Hua-shan Shi
exaly +2 more sources
Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
Scientific Reports, 2021 Mammalian cytosine DNA methylation (5mC) is associated with the integrity of the genome and the transcriptional status of nuclear DNA. Due to technical limitations, it has been less clear if mitochondrial DNA (mtDNA) is methylated and whether 5mC has a ...
Chloe Goldsmith +10 more
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Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma. [PDF]
PLoS ONE, 2010 The TGF-beta family of mediators are thought to play important roles in the regulation of inflammation and airway remodelling in asthma. All three mammalian isoforms of TGF-beta, TGF-beta(1-3), are expressed in the airways and TGF-beta(1) and -beta(2 ...
Stephen E Bottoms +4 more
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TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. [PDF]
PLoS ONE, 2013 The FET cell line, derived from an early stage colon carcinoma, is non-tumorigenic in athymic nude mice. Engineered FET cells that express TGF-α (FETα) display constitutively active EGFR/ErbB signaling.
Liying Geng +4 more
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Tgf-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia. [PDF]
PLoS ONE, 2014 The cystic fibrosis transmembrane conductance regulator (CFTR) and Calcium-activated Chloride Conductance (CaCC) each play critical roles in maintaining normal hydration of epithelial surfaces including the airways and colon.
Hongtao Sun +9 more
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