Heliyon, 2023 Background: TGF-beta signaling is a key regulator of immunity and multiple cellular behaviors in cancer. However, the prognostic and therapeutic role of TGF-beta signaling-related genes in ovarian cancer (OV) remains unexplored.
Ruo-Peng Liang
exaly +3 more sources
GENE POLYMORPHISIM OF TRANSFORMING GROWTH FACTOR Beta 1(TGF-β1) IN AUTISM SPECTRUM DISORDER ASD IN BASRAH [PDF]
Basrah Journal of Veterinary Research, 2020 Transforming growth factor-β1 (TGF-β1) is an important immune regulatorcritical for immune homeostasis. Accumulating evidence suggests that TGF-β1 has acrucial regulatory role in CNS development and potential implications forneurogenesis ...
Khulood, Abdulrazaq Kaleel +1 more
doaj +1 more source
Low biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
Scientific Reports, 2021 Mammalian cytosine DNA methylation (5mC) is associated with the integrity of the genome and the transcriptional status of nuclear DNA. Due to technical limitations, it has been less clear if mitochondrial DNA (mtDNA) is methylated and whether 5mC has a ...
Chloe Goldsmith +10 more
doaj +1 more source
Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma. [PDF]
PLoS ONE, 2010 The TGF-beta family of mediators are thought to play important roles in the regulation of inflammation and airway remodelling in asthma. All three mammalian isoforms of TGF-beta, TGF-beta(1-3), are expressed in the airways and TGF-beta(1) and -beta(2 ...
Stephen E Bottoms +4 more
doaj +1 more source
TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. [PDF]
PLoS ONE, 2013 The FET cell line, derived from an early stage colon carcinoma, is non-tumorigenic in athymic nude mice. Engineered FET cells that express TGF-α (FETα) display constitutively active EGFR/ErbB signaling.
Liying Geng +4 more
doaj +1 more source
Tgf-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia. [PDF]
PLoS ONE, 2014 The cystic fibrosis transmembrane conductance regulator (CFTR) and Calcium-activated Chloride Conductance (CaCC) each play critical roles in maintaining normal hydration of epithelial surfaces including the airways and colon.
Hongtao Sun +9 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2016 Human respiratory syncytial virus (RSV) is a lung tropic virus causing severe airway diseases including bronchiolitis and pneumonia among infants, children and immuno-compromised individuals.
Swechha Pokharel +2 more
doaj +1 more source
Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth. [PDF]
PLoS ONE, 2010 BACKGROUND: Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced. TGF-beta, a potent inhibitor of terminal osteoblast (
Kyoko Takeuchi +14 more
doaj +1 more source
Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. [PDF]
PLoS ONE, 2009 BACKGROUND: Chronic hepatitis C virus (HCV) infection and associated liver cirrhosis represent a major risk factor for hepatocellular carcinoma (HCC) development.
Serena Battaglia +8 more
doaj +1 more source
Transforming growth factor beta is sequestered into an inactive pool by lipoproteins
Journal of Lipid Research, 1997 Elevated plasma concentrations of low density lipoprotein (LDL) and very-low density lipoprotein (VLDL) have been correlated with the development of atherosclerosis. These lipoproteins may promote atherogenesis by direct deposition of lipid in the vessel
D J Grainger +3 more
doaj +1 more source