Results 21 to 30 of about 270,164 (307)
TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells. [PDF]
PLoS ONE, 2009 Immune dysregulation in HIV-1 infection is associated with increased expression of inhibitory molecules such as CTLA-4, TGF-beta, and IL-10. In this study we examined one potential mechanism for regulating TGF-beta and IL-10 expression by HIV-specific ...
Mohamed Elrefaei +6 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2005 Background TGF beta and its receptors are present in both germ cells and somatic cells of the male gonad. However, knock-out strategies for studying spermatogenesis regulation by TGF beta have been disappointing since TGF beta-or TGF beta receptor-null ...
Sabido Odile +4 more
doaj +1 more source
Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.
PLoS ONE, 2008 BackgroundThe 3-hydroxy-3-methylglutaryl CoA reductase inhibitors (also called statins) exert proven beneficial effects on cardiovascular diseases. Recent data suggest a protective role for Transforming Growth Factor-beta (TGF-beta) in atherosclerosis by
Juan Rodríguez-Vita +9 more
doaj +1 more source
TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. [PDF]
PLoS ONE, 2009 Pericyte-endothelial cell (EC) interactions are critical to both vascular development and vessel stability. We have previously shown that TGF-beta signaling between EC and mural cells participates in vessel stabilization in vitro.
Tony E Walshe +5 more
doaj +1 more source
The Journal of Poultry Science, 2007 Our goal was to determine whether there is any correlation between the mRNA expressions of transforming growth factor β (TGFβ)-isoforms/their receptors and the fertility in chicken sperm stored in vitro for different times. The semen collected
Shubash C. Das +2 more
doaj +1 more source
Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway [PDF]
, 2012 Protein phosphatases play a key role in balancing the cellular responses to the transforming growth factor-beta (TGF beta) signals. Several protein phosphatases have been attributed roles in the regulation of the TGF beta pathway. Among these.
Bruce, David L. +4 more
core +3 more sources
TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm [PDF]
, 2017 Objective-Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGF beta (transforming growth factor-beta) activity-a guardian of vascular integrity ...
Clément, Marc +12 more
core +2 more sources
BMC Genomics, 2007 Background TGF-beta is one of the key cytokines implicated in various disease processes including cancer. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells and in contrast, acts as a pro-tumour cytokine by promoting tumour ...
Takahashi Takashi +6 more
doaj +1 more source
BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses. [PDF]
PLoS ONE, 2009 BRCA1 is a key regulatory protein participating in cell cycle checkpoint and DNA damage repair networks. BRCA1 plays important roles in protecting numerous cellular processes in response to cell damaging signals. Transforming growth factor-beta (TGF-beta)
Huchun Li +4 more
doaj +1 more source
The Journal of Poultry Science, 2010 The aim of present study was to determine whether the expression of transforming growth factor-βs (TGFβs) in the utero-vaginal junction (UVJ) of hen oviduct was changed by the stimulation with sperm.
Shubash C. Das +2 more
doaj +1 more source