TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells. [PDF]
PLoS ONE, 2009 Immune dysregulation in HIV-1 infection is associated with increased expression of inhibitory molecules such as CTLA-4, TGF-beta, and IL-10. In this study we examined one potential mechanism for regulating TGF-beta and IL-10 expression by HIV-specific ...
Mohamed Elrefaei +6 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2005 Background TGF beta and its receptors are present in both germ cells and somatic cells of the male gonad. However, knock-out strategies for studying spermatogenesis regulation by TGF beta have been disappointing since TGF beta-or TGF beta receptor-null ...
Sabido Odile +4 more
doaj +1 more source
TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons. [PDF]
, 2014 Members of the transforming growth factor (TGF)-b family govern a wide range of mechanisms in brain development and in the adult, in particular neuronal/glial differentiation and survival, but also cell cycle regulation and neural stem cell maintenance ...
Strauss, O. +27 more
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Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.
PLoS ONE, 2008 BackgroundThe 3-hydroxy-3-methylglutaryl CoA reductase inhibitors (also called statins) exert proven beneficial effects on cardiovascular diseases. Recent data suggest a protective role for Transforming Growth Factor-beta (TGF-beta) in atherosclerosis by
Juan Rodríguez-Vita +9 more
doaj +1 more source
The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy [PDF]
, 2011 Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of tubulointerstitial fibrosis is epithelial-to-mesenchymal transition ...
Hills, Claire E. +3 more
core +1 more source
The Journal of Poultry Science, 2007 Our goal was to determine whether there is any correlation between the mRNA expressions of transforming growth factor β (TGFβ)-isoforms/their receptors and the fertility in chicken sperm stored in vitro for different times. The semen collected
Shubash C. Das +2 more
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TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. [PDF]
PLoS ONE, 2009 Pericyte-endothelial cell (EC) interactions are critical to both vascular development and vessel stability. We have previously shown that TGF-beta signaling between EC and mural cells participates in vessel stabilization in vitro.
Tony E Walshe +5 more
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Biological activity differences between TGF-β1 and TGF-β3 correlate with differences in the rigidity and arrangement of their component monomers [PDF]
, 2014 TGF-ß1, -ß2, and -ß3 are small, secretedsignaling proteins. They share 71-80% sequence identityand signal through the same receptors, yet the isoform-specificnull mice have distinctive phenotypes and are inviable. Thereplacement of the coding sequence of
Hinck, Andrew P. +5 more
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BMC Genomics, 2007 Background TGF-beta is one of the key cytokines implicated in various disease processes including cancer. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells and in contrast, acts as a pro-tumour cytokine by promoting tumour ...
Takahashi Takashi +6 more
doaj +1 more source
TGF-b2 induction regulates invasiveness of theileria-transformed leukocytes and disease susceptibility [PDF]
, 2010 Theileria parasites invade and transform bovine leukocytes causing either East Coast fever (T. parva), or tropical theileriosis (T. annulata). Susceptible animals usually die within weeks of infection, but indigenous infected cattle show markedly reduced
Regina Lizundia +69 more
core +2 more sources