Results 11 to 20 of about 270,164 (307)

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses [PDF]

The EMBO Journal, 2002
Through the action of its membrane-bound type I receptors, transforming growth factor-beta (TGF-beta) elicits a wide range of cellular responses that regulate cell proliferation, differentiation and apoptosis. Many of the signaling responses induced by TGF-beta are mediated by Smad proteins, but certain evidence has suggested that TGF-beta can also ...
Li, Yu, Mindy C, Hébert, Ying E, Zhang
openaire   +2 more sources

The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β [PDF]

, 2013
It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved.
Boon, Louis, Gloudemans, Anouk K, Guilliams, Martin, Hammad, Hamida, Harris, Nicola L, Hendriks, Rudi W, Hoogsteden, Henk C, Lambrecht, Bart, Ozir-Fazalalikhan, Arifa, Plantinga, Maud, Smits, Hermelijn H, van der Ham, Alwin, Willart, Monique, Yazdanbakhsh, Maria   +13 more
core   +11 more sources

Tgf-Beta inhibition restores terminal osteoblast differentiation to suppress myeloma growth. [PDF]

PLoS ONE, 2010
BACKGROUND: Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone lesions, in which bone formation is impaired and osteoclastic bone resorption is enhanced. TGF-beta, a potent inhibitor of terminal osteoblast (
Kyoko Takeuchi, Masahiro Abe, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Shinsuke Kido, Takeshi Harada, Osamu Tanaka, Hirokazu Miki, Shingen Nakamura, Ayako Nakano, Kumiko Kagawa, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto   +14 more
doaj   +1 more source

Splenic CD8(+) T cells secrete TGF-beta 1 to exert suppression in mice with anterior chamber-associated immune deviation [PDF]

, 2009
Background CD8(+) regulatory T cells (Treg) have been considered to be involved in a model of ocular-induced tolerance, known as anterior chamber-associated immune deviation (ACAID).
He, H., Huang, X.K., Jiang, L.Q., Kijlstra, A., Lin, X.M., Yang, P.Z., Zhou, H.Y.   +6 more
core   +2 more sources

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources

A mathematical model quantifies proliferation and motility effects of TGF--$\beta$ on cancer cells [PDF]

, 2008
Transforming growth factor (TGF) $\beta$ is known to have properties of both a tumor suppressor and a tumor promoter. While it inhibits cell proliferation, it also increases cell motility and decreases cell--cell adhesion.
Arteaga, Carlos L., Bryce, Nicole, Estrada, Lourdes, Hinow, Peter, Wang, Shizhen Emily, Weaver, Alissa M., Webb, Glenn F.   +6 more
core   +3 more sources

Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. [PDF]

PLoS ONE, 2009
BACKGROUND: Chronic hepatitis C virus (HCV) infection and associated liver cirrhosis represent a major risk factor for hepatocellular carcinoma (HCC) development.
Serena Battaglia, Nassima Benzoubir, Soizic Nobilet, Pierre Charneau, Didier Samuel, Anna Linda Zignego, Azeddine Atfi, Christian Bréchot, Marie-Françoise Bourgeade   +8 more
doaj   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Abdul HM, Alice L. Yu, Aslan M, Bilska A, Buniatian GH, Cabell L, Carini M, Chong MS, Esposito G, Fuchshofer R, Fuchshofer R, Fukuchi T, Furuyoshi N, Gaitanaki C, Hatten ME, He S, Hernandez MR, Hernandez MR, Hernandez MR, Hernandez MR, Hodges NJ, Ihnat MA, Izzotti A, Jerome Moriniere, Kobayashi S, Kumar DM, Lambert W, Louhelainen M, Lutjen-Drecoll E, Malone PE, Markesbery WR, Meldrum B, Mozaffarieh M, Neufeld AH, Neumann C, Ohia SE, Oksala NK, Oksala NK, Pena JD, Picht G, Proell V, Ridet JL, Sacca SC, Salinthone S, Samali A, Sharp FR, Shin JH, Smith AR, Sturrock A, Tezel G, Tezel G, Tripathi RC, Ulrich Welge-Lussen, Valencia A, Veach J, Várkonyi T, Yang KL, Yang P, Yu AL, Yu AL, Zimmer DB   +60 more
core   +1 more source

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core   +1 more source

Transforming growth factor beta is sequestered into an inactive pool by lipoproteins

Journal of Lipid Research, 1997
Elevated plasma concentrations of low density lipoprotein (LDL) and very-low density lipoprotein (VLDL) have been correlated with the development of atherosclerosis. These lipoproteins may promote atherogenesis by direct deposition of lipid in the vessel
D J Grainger, C D Byrne, C M Witchell, J C Metcalfe   +3 more
doaj   +1 more source