Results 31 to 40 of about 270,164 (307)

Association of Marek's Disease induced immunosuppression with activation of a novel regulatory T cells in chickens.

PLoS Pathogens, 2017
Marek's Disease Virus (MDV) is an alphaherpesvirus that infects chickens, transforms CD4+ T cells and causes deadly lymphomas. In addition, MDV induces immunosuppression early during infection by inducing cell death of the infected lymphocytes, and ...
Angila Gurung, Nitin Kamble, Benedikt B Kaufer, Ansar Pathan, Shahriar Behboudi   +4 more
doaj   +1 more source

Cholesterol Suppresses Cellular TGF‐beta Responsiveness by Increasing TGF‐beta Receptor Accumulation in Lipid raft/Caveolae Microdomains and Alterring TGF‐beta Binding to TGF‐beta Receptors

The FASEB Journal, 2008
TGF‐β responsiveness in cultured cells can be modulated by TGF‐β partitioning between lipid raft/caveolae‐ and clathrin‐mediated endocytosis pathways. The ratio of TGF‐β binding to TβR‐II and TβR‐I on the cell surface has recently been found to be a signal that controls TGF‐β partitioning between these pathways.
Chun‐Lin Chen, Shuan Shian Huang, Jung San Huang   +2 more
openaire   +1 more source

TGF-beta TGF-beta RII CLC-3 axis promotes cognitive disorders in diabetes

Frontiers in Bioscience, 2019
Transforming growth factor beta (TGF-beta) and Chloride channel-3 (CLC-3) are critical for inflammatory response, cellular proliferation and apoptosis in hippocampus neurons. However, the relationship between CLC-3 and TGF-beta/TGF-beta Receptor II (RII) pathway in diabetic encephalopathy (DE) is unknown.
Feiyan, Fan, Jing, Qi, Nan, Liu, Zhen, Wang, Wenshi, Wang, Hui, Liu, Xiaoshan, Xu, Guangfeng, Chen, Xin, Wang, Hongwei, Yang, Mark, Johnson, Yanyang, Tu, Tao, Liu, Jianfang, Fu   +13 more
openaire   +2 more sources

Is telomerase reactivation associated with the down-regulation of TGF β receptor-II expression in human breast cancer?

Cancer Cell International, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells.
Thomas Valene, Newbold Robert F, Elkak Abd E, Mokbel Kefah   +3 more
doaj   +1 more source

The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]

, 2011
Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P., Traynor, Ryan, Vogt, Janis   +2 more
core   +3 more sources

Transforming growth factor-beta stimulation of lung fibroblast prostaglandin E2 production. [PDF]

, 1989
Transforming growth factor-beta (TGF beta) stimulated the production of total protein, collagen, and fibronectin by normal human lung fibroblasts.
Diaz, Arturo, Jimenez, Sergio A., Varga, John   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Accumulation, localization, and compartmentation of transforming growth factor beta during endochondral bone development. [PDF]

, 1988
Endochondral bone formation was induced in postnatal rats by implantation of demineralized rat bone matrix. Corresponding control tissue was generated by implanting inactive extracted bone matrix, which did not induce bone formation.
Carrington, JL, Flanders, KC, Reddi, AH, Roberts, AB, Roche, NS   +4 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Botulinum Toxin A for the Treatment of Keloids [PDF]

, 2012
Introduction: Keloids are the result of excessive scar tissue formation. Besides their poor aesthetic appearance, keloids can be associated with severe clinical symptoms such as pain, itching, and rigidity.
Bureik, D., Dombrowski, Yvonne, Gauglitz, Gerd, Pavicic, T., Ruzicka, Thomas, Schauber, Jürgen   +5 more
core   +1 more source