Results 91 to 100 of about 13,045 (219)

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Additional file 1: of FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway

, 2017
Supplementary Methods. (DOC 37 kb)
Shi, Jie-Yi, Ma, Li-Jie, Zhang, Ji-Wei, Duan, Meng, Ding, Zhen-Bin, Liu-Xiao Yang, Cao, Ya, Zhou, Jian, Fan, Jia, Xiaoming Zhang, Zhao, Ying-Jun, Wang, Xiao-Ying, Gao, Qiang   +12 more
openaire   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

TGF‐β transactivates EGFR and facilitates breast cancer migration and invasion through canonical Smad3 and ERK/Sp1 signaling pathways

Molecular Oncology, 2018
Transforming growth factor‐beta (TGF‐β) functions as a potent proliferation inhibitor and apoptosis inducer in the early stages of breast cancer, yet promotes cancer aggressiveness in the advanced stages. The dual effect of TGF‐β on cancer development is
Yuanyuan Zhao, Jing Ma, Yanling Fan, Zhiyong Wang, Ran Tian, Wei Ji, Fei Zhang, Ruifang Niu   +7 more
doaj   +1 more source

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1Research in context

EBioMedicine, 2019
Background: Hyper-activation of TGF-β signaling is critically involved in progression of hepatocellular carcinoma (HCC). However, the events that contribute to the dysregulation of TGF-β pathway in HCC, especially at the post-translational level, are not
Boshi Wang, Xiaoli Xu, Zhaojuan Yang, Li Zhang, Yun Liu, Aihui Ma, Guiqin Xu, Ming Tang, Tiantian Jing, Lin Wu, Yongzhong Liu   +10 more
doaj   +1 more source

Additional file 3: of Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis

, 2018
Figure S3. Every-other-day injection of bleomycin for 2 weeks induced significant skin fibrosis. Back skin of NaCl- or bleomycin-injected mice was harvested on day 14 and stained with H&E. Scale bar = 100 Îźm. n = 3 in each group. (PDF 80 kb)
Luong, Vu, Chino, Takenao, Oyama, Noritaka, Matsushita, Takashi, Sasaki, Yoko, Ogura, Dai, Niwa, Shin-ichiro, Biswas, Tanima, Hamasaki, Akiyuki, Fujita, Mikako, Okamoto, Yoshinari, Otsuka, Masami, Ihn, Hironobu, Hasegawa, Minoru   +13 more
openaire   +1 more source

Infeksi Cacing Tidak Berpengaruh terhadap Kadar Transforming Growth Factor (TGF)-β dan Kejadian Dermatitis Atopik pada Anak

Jurnal Kedokteran Brawijaya, 2015
Infeksi cacing melalui kemampuannya memacu proliferasi sel T regulator dilaporkan dapat mempengaruhi manifestasi klinik dari alergi. Selain Interleukin (IL)-10, Transforming Growth Factor (TGF)-β merupakan sitokin yang di lepaskan oleh sel T regulator.
Nadiah Soleman Mukhasin, Sitti Wahyuni, Faridha S Ilyas, Safruddin Amin, R Satriono, Farida Tabri   +5 more
openaire   +2 more sources

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Additional file 1: of Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis

, 2018
Figure S1. The molecular structure of HPH-15. (PDF 7 kb)
Luong, Vu, Chino, Takenao, Oyama, Noritaka, Matsushita, Takashi, Sasaki, Yoko, Ogura, Dai, Niwa, Shin-ichiro, Biswas, Tanima, Hamasaki, Akiyuki, Fujita, Mikako, Okamoto, Yoshinari, Otsuka, Masami, Ihn, Hironobu, Hasegawa, Minoru   +13 more
openaire   +1 more source

TGF-β/Smad signaling in renal fibrosis

Frontiers in Physiology, 2015
TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis. TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects. Among them, Smad signaling is recognized as a major pathway of TGF-β signaling in progressive renal fibrosis. During fibrogenesis, Smad3 is highly activated, which is
Meng, Xiao-Ming, Tang, Patrick Ming-Kuen, Li, Jun, Lan, Hui Yao   +3 more
openaire   +3 more sources