Results 1 to 10 of about 1,831,608 (241)

Functional Biomaterials for Treatment of Chronic Wound

Frontiers in Bioengineering and Biotechnology, 2020
The increasing number of patients with chronic wounds caused by diseases, such as diabetes, malignant tumors, infections, and vasculopathy, has caused severe economic and social burdens.
Xi Zhang, Xi Zhang, Wentao Shu, Qinghua Yu, Wenrui Qu, Yinan Wang, Yinan Wang, Rui Li   +7 more
doaj   +1 more source

Increased Levels of BAMBI Inhibit Canonical TGF-β Signaling in Chronic Wound Tissues

Cells, 2023
Chronic wounds affect more than 2% of the population worldwide, with a significant burden on affected individuals, healthcare systems, and societies. A key regulator of the entire wound healing cascade is transforming growth factor beta (TGF-β), which ...
Sabrina Ehnert, Helen Rinderknecht, Chao Liu, Melanie Voss, Franziska M. Konrad, Wiebke Eisler, Dorothea Alexander, Kristian-Christos Ngamsri, Tina Histing, Mika F. Rollmann, Andreas K. Nussler   +10 more
doaj   +1 more source

A novel model of chronic wounds: importance of redox imbalance and biofilm-forming bacteria for establishment of chronicity. [PDF]

PLoS ONE, 2014
Chronic wounds have a large impact on health, affecting ∼6.5 M people and costing ∼$25B/year in the US alone. We previously discovered that a genetically modified mouse model displays impaired healing similar to problematic wounds in humans and that ...
Sandeep Dhall, Danh Do, Monika Garcia, Dayanjan Shanaka Wijesinghe, Angela Brandon, Jane Kim, Antonio Sanchez, Julia Lyubovitsky, Sean Gallagher, Eugene A Nothnagel, Charles E Chalfant, Rakesh P Patel, Neal Schiller, Manuela Martins-Green   +13 more
doaj   +1 more source

Biofilm and Equine Limb Wounds

Animals, 2021
In chronic wounds in humans, biofilm formation and wound chronicity are linked, as biofilms contribute to chronic inflammation and delayed healing. Biofilms are aggregates of bacteria, and living as biofilms is the default mode of bacterial life; within ...
Elin Jørgensen, Thomas Bjarnsholt, Stine Jacobsen   +2 more
doaj   +1 more source

Modern Approaches for Treatment of Patients with Chronic Wounds in Ambulatory Setting in General Hospital Dr. "Jože Potrč", Ptuj.

Albanian Journal of Trauma and Emergency Surgery, 2019
Chronic wounds represent an enormous health, social and economic burden in modern society. With the increasing incidence of diabetes and obesity as well as the ageing of the population, we correspondingly expect a rise in the incidence of chronic wounds.
Skender Veliu, Jasmina Kröpfl, Dominika Vrbnjak   +2 more
doaj   +1 more source

Multifunctional hydrogels for chronic wounds repairing

Biosurface and Biotribology, 2023
Because of their tissue‐like mechanical performances, high biocompatibility, and adjustable functionality, hydrogels have become increasingly attractive materials for promoting wound healing.
Xiao Wang, Rong Hu, Lu Han, Xiong Lu
doaj   +1 more source

Prevalence and antibiotic susceptibility of bacteria from acute and chronic wounds in Malaysian subjects

Journal of Infection in Developing Countries, 2015
Introduction: Chronic wounds represent a major health burden worldwide. It has been hypothesized that the polymicrobial nature of wounds plays an important role in their healing process. Thus, a review of pathogen frequency and susceptibility patterns in
Shin Yee Wong, Rishya Manikam, Sekaran Muniandy   +2 more
doaj   +1 more source

High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation

Frontiers in Cellular and Infection Microbiology, 2020
Diabetics chronic wounds are characterized by high levels of oxidative stress (OS) and are often colonized by biofilm-forming bacteria that severely compromise healing and can result in amputation.
Jane H. Kim, Paul R. Ruegger, Elyson Gavin Lebig, Samantha VanSchalkwyk, Daniel R. Jeske, Ansel Hsiao, James Borneman, Manuela Martins-Green   +7 more
doaj   +1 more source

Antiseptic pyolytics and warming wet compresses improve the prospect of healing chronic wounds

Exploration of Medicine, 2023
Infection and suppuration of chronic wounds reduce the effectiveness of their treatment with a course of antibiotics and antiseptics combined with frequently renewed dressings.
Aleksandr Urakov, Natalya Urakova, Evgeniy Fisher, Albina Shchemeleva, Anastasia Stolyarenko, Valentina Martiusheva, Marina Zavarzina   +6 more
doaj   +1 more source

Global trends in research of high-throughput sequencing technology associated with chronic wounds from 2002 to 2022: A bibliometric and visualized study

Frontiers in Surgery, 2023
BackgroundChronic wounds are a complex medical problem. With the difficulty of skin healing, the microbial ecology of chronic wounds is an essential factor affecting wound healing.
Hao Meng, Yu Peng, Yu Peng, Pinxue Li, Jianlong Su, Yufeng Jiang, Xiaobing Fu, Xiaobing Fu   +7 more
doaj   +1 more source