Results 1 to 10 of about 273,340 (118)

Challenges in the management of chronic wound infections

Journal of Global Antimicrobial Resistance, 2021
: Objectives: Chronic wound infections may delay the healing process and are responsible for a significant burden on healthcare systems. Since inappropriate management may commonly occur in the care of these patients, this review aims to provide a ...
Marco Falcone, Barbara De Angelis, Federico Pea, Alessandro Scalise, Stefania Stefani, Rolando Tasinato, Orazio Zanetti, Luca Dalla Paola   +7 more
doaj   +3 more sources

Research progress on TWEAK/Fn14 signaling in chronic wound healing [PDF]

Frontiers in Surgery
Chronic wounds are characterized by persistent inflammation and altered microenvironments, exhibiting prolonged healing and difficult repair, presenting significant therapeutic challenges.
Bo Liu, Bo Liu, Weimin Wu, Weimin Wu, Weigang Hu, Weigang Hu, Huarong Zheng, Huarong Zheng, Tianyao Lan, Tianyao Lan   +9 more
doaj   +2 more sources

The emerging translational potential of GDF11 in chronic wound healing

Journal of Orthopaedic Translation, 2022
Chronic skin wounds impose immense suffers and economic burdens. Current research mainly focuses on acute wound management which exhibits less effective in chronic wound healing.
Yuan Li, Yucong Li, Linlong Li, Haixing Wang, Bin Wang, Lu Feng, Sien Lin, Gang Li   +7 more
doaj   +1 more source

Advances of hydrogel combined with stem cells in promoting chronic wound healing

Frontiers in Chemistry, 2022
Wounds can be divided into two categories, acute and chronic. Acute wounds heal through the normal wound healing process. However, chronic wounds take longer to heal, leading to inflammation, pain, serious complications, and an economic burden of ...
Qirong Li, Qirong Li, Dongxu Wang, Ziping Jiang, Rong Li, Tianyi Xue, Chao Lin, Yongzhi Deng, Ye Jin, Baozhen Sun   +9 more
doaj   +1 more source

CLINICAL AND MORPHOLOGICAL FEATURES OF ACUTE AND CHRONIC WOUNDS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2021
Background. The chronicity of the wound is a factor leading to a greater number of postoperative complications when performing plastic closure of wound defects and requires the use of special methods of preoperative preparation.
Slavnikov I. A. , Dundarov Z. A., Yarets Y. I.   +2 more
doaj   +1 more source

Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment

Frontiers in Bioengineering and Biotechnology, 2023
Chronic non-healing wounds have posed a severe threat to patients mentally and physically. Behavior dysregulation of remaining cells at wound sites is recognized as the chief culprit to destroy healing process and hinders wound healing.
Qian Wei, Xi Liu, Jian-Long Su, Ya-Xi Wang, Zi-Qiang Chu, Kui Ma, Kui Ma, Kui Ma, Qi-Lin Huang, Hai-Hong Li, Xiao-Bing Fu, Xiao-Bing Fu, Xiao-Bing Fu, Cui-Ping Zhang, Cui-Ping Zhang, Cui-Ping Zhang   +15 more
doaj   +1 more source

The Impact of Prolonged Inflammation on Wound Healing

Biomedicines, 2022
The treatment of chronic wounds still challenges modern medicine because of these wounds’ heterogenic pathophysiology. Processes such as inflammation, ischemia and bacterial infection play major roles in the progression of a chronic wound.
Judith C. J. Holzer-Geissler, Simon Schwingenschuh, Martin Zacharias, Johanna Einsiedler, Sonja Kainz, Peter Reisenegger, Christian Holecek, Elisabeth Hofmann, Barbara Wolff-Winiski, Hermann Fahrngruber, Thomas Birngruber, Lars-Peter Kamolz, Petra Kotzbeck   +12 more
doaj   +1 more source

Bone Marrow-Derived Mesenchymal Stem Cells Restored High-Fat-Fed Induced Hyperinsulinemia in Rats at Early Stage of Type 2 Diabetes Mellitus

Cell Transplantation, 2020
Numerous studies have proposed the transplantation of mesenchymal stem cells (MSCs) in the treatment of typical type 2 diabetes mellitus (T2DM). We aimed to find a new strategy with MSC therapy at an early stage of T2DM to efficiently prevent the ...
Gongchi Li, Han Peng, Shen Qian, Xinhua Zou, Ye Du, Zhi Wang, Lijun Zou, Zibo Feng, Jing Zhang, Youpeng Zhu, Huamin Liang, Binghui Li   +11 more
doaj   +1 more source

Challenges in Healing Wound: Role of Complementary and Alternative Medicine

Frontiers in Nutrition, 2022
Although the word wound sounds like a simple injury to tissue, individual's health status and other inherent factors may make it very complicated. Hence, wound healing has gained major attention in the healthcare. The biology wound healing is precise and
Prakash Monika, Mathikere Naganna Chandraprabha, Annapoorni Rangarajan, P. Veena Waiker, Kotamballi N. Chidambara Murthy   +4 more
doaj   +1 more source

High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation

Frontiers in Cellular and Infection Microbiology, 2020
Diabetics chronic wounds are characterized by high levels of oxidative stress (OS) and are often colonized by biofilm-forming bacteria that severely compromise healing and can result in amputation.
Jane H. Kim, Paul R. Ruegger, Elyson Gavin Lebig, Samantha VanSchalkwyk, Daniel R. Jeske, Ansel Hsiao, James Borneman, Manuela Martins-Green   +7 more
doaj   +1 more source