Results 51 to 60 of about 2,112,620 (360)
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
core +2 more sources
TGF-β in developmental and fibrogenic EMTs
Seminars in Cancer Biology, 2022 TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs) during development and wound healing and in disease conditions such as fibrosis and cancer.
Jun Ho Lee, J. Massagué
semanticscholar +1 more source
TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
International Journal of Molecular Sciences, 2019 Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation, migration, and the differentiation of a plethora of different cell types.
Y. Hao, David A. Baker, P. ten Dijke
semanticscholar +1 more source
Annual Review of Immunology, 2022 Transforming growth factor β (TGF-β) is a key cytokine regulating the development, activation, proliferation, differentiation, and death of T cells. In CD4+ T cells, TGF-β maintains the quiescence and controls the activation of naive T cells.
Wan-tao Chen
semanticscholar +1 more source
Frontiers in Immunology, 2022 Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian development and disease, particularly cancer, has constantly been updated.
Baode Chen +4 more
doaj +1 more source
New insights into TGF-β/Smad signaling in tissue fibrosis.
Chemico-Biological Interactions, 2018 Transforming growth factor-β1 (TGF-β1) is considered as a crucial mediator in tissue fibrosis and causes tissue scarring largely by activating its downstream small mother against decapentaplegic (Smad) signaling. Different TGF-β signalings play different
He-He Hu +6 more
semanticscholar +1 more source
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
Journal of Hematology & Oncology, 2022 Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in the late stages of cancer.
Xueke Shi +9 more
semanticscholar +1 more source
Jurnal Kedokteran Brawijaya, 2015 Infeksi cacing melalui kemampuannya memacu proliferasi sel T regulator dilaporkan dapat mempengaruhi manifestasi klinik dari alergi. Selain Interleukin (IL)-10, Transforming Growth Factor (TGF)-β merupakan sitokin yang di lepaskan oleh sel T regulator.
Nadiah Soleman Mukhasin +5 more
openaire +2 more sources
HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]
, 2015 The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone +6 more
core +1 more source
Specificity, versatility, and control of TGF-β family signaling
Science Signaling, 2019 Molecular function and pathway cross-talk in TGF-β signaling reveal its complexity and open questions. Gloss The transforming growth factor–β (TGF-β) family of secreted proteins is implicated in the control of widely diverse physiologies and its ...
R. Derynck, Erine H. Budi
semanticscholar +1 more source