Results 31 to 40 of about 320,405 (317)

MOESM1 of Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition

, 2019
Additional file 1. Supplemental information including figures.
Congcong Lu, Sidoli, Simone, Kulej, Katarzyna, Ross, Karen, Wu, Cathy, Garcia, Benjamin   +5 more
openaire   +1 more source

The TGF-β Family in Glioblastoma

International Journal of Molecular Sciences
Members of the transforming growth factor β (TGF-β) family have been implicated in the biology of several cancers. In this review, we focus on the role of TGFβ and bone morphogenetic protein (BMP) signaling in glioblastoma. Glioblastoma (GBM) is the most common malignant brain tumor in adults; it presents at a median age of 64 years, but can occur at ...
Irene Golán-Cancela, Laia Caja
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Rat testicular germ cells and sertoli cells release different types of bioactive transforming growth factor beta in vitro

Reproductive Biology and Endocrinology, 2003
Several in vivo studies have reported the presence of immunoreactive transforming growth factor-β's (TGF-β's) in testicular cells at defined stages of their differentiation.
Themmen Axel PN, Hoogerbrugge Jos W, Haagmans Bart L, Teerds Katja J   +3 more
doaj   +1 more source

Crosstalk between Shh and TGF-β signaling in cyclosporine-enhanced cell proliferation in human gingival fibroblasts. [PDF]

PLoS ONE, 2013
BACKGROUND: Immunosuppressant cyclosporine-A induces gingival hyperplasia, which is characterized by increased fibroblast proliferation and overproduction of extracellular matrix components and regulated by transforming growth factor-beta (TGF-β).
Yi Chung, Earl Fu
doaj   +1 more source

Additional file 1: of LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer

, 2019
Table S1. Oligonucleotides used for RT-qPCR, plasmid construction, RNA pull-down, siRNA, and GapmeR. (DOCX 25 kb)
Luo, Kaili, Geng, Jingwen, Zhang, Qinkai, Xu, Yesha, Zhou, Xunzhu, Huang, Zheng, Shi, Ke-Qing, Pan, Chenwei, Wu, Jianmin   +8 more
openaire   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Additional file 8: of LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer

, 2019
Table S2. Gene differential expression in HCT-116/GapC9 and HCT-116/GapNC cells. (DOCX 136 kb)
Luo, Kaili, Geng, Jingwen, Zhang, Qinkai, Xu, Yesha, Zhou, Xunzhu, Huang, Zheng, Shi, Ke-Qing, Pan, Chenwei, Wu, Jianmin   +8 more
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source