Results 21 to 30 of about 320,405 (317)

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy

open access: yesAdvanced Science, 2022
Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists.
Xiao Wang   +11 more
doaj   +1 more source

Lumican promotes joint fibrosis through TGF‐β signaling

open access: yesFEBS Open Bio, 2020
Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form fibrotic scar tissue and adhesions within joint capsules.
Dahai Xiao   +8 more
doaj   +1 more source

Editorial Special Issue TGF-Beta/BMP Signaling Pathway

open access: yesCells, 2020
The transforming growth factor β (TGF-β) superfamily plays key roles in development and tissue homeostasis, controlling the maintenance and regeneration of mature tissues [...]
Isabel Fabregat   +2 more
doaj   +1 more source

Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart. [PDF]

open access: yesPLoS ONE, 2011
BACKGROUND: Neuroendocrine activation and local mediators such as transforming growth factor-β₁ (TGF-β₁) contribute to the pathobiology of cardiac hypertrophy and failure, but the underlying mechanisms are incompletely understood.
Michael Huntgeburth   +13 more
doaj   +1 more source

TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy

open access: yesFrontiers in Immunology, 2022
Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes, such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides, TGF-β plays a vital role in diseases, including cancer.
Ming Yi   +6 more
doaj   +1 more source

Hubungan Kadar TGF-β1 dan IFN-ɣ dengan Indeks Kronisitas Nefritis Lupus

open access: yesJurnal Kedokteran Brawijaya, 2013
Meskipun perbaikan penatalaksanaan terapi telah dilakukan dalam dua dekade terakhir , tetapi prognosis nefritis lupus tetap  tidak  memuaskan.  Oleh  karena  itu  diperlukan  suatu  biomarker  yang  dapat  menggambarkan  aktivitas  penyakit. Penelitian ini  dilakukan untuk untuk melihat peran TGF-β1 urin dan IFN-ɣ  urin sebagai ...
Indah Jayani   +2 more
openaire   +2 more sources

Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis

open access: yesFrontiers in Oncology, 2018
The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of different cellular processes that are essential for tissue and organ homeostasis.
Isabel Fabregat   +4 more
doaj   +1 more source

A Tight Control of Non-Canonical TGF-β Pathways and MicroRNAs Downregulates Nephronectin in Podocytes

open access: yesCells, 2022
Nephronectin (NPNT) is an extracellular matrix protein in the glomerular basement membrane that is produced by podocytes and is important for the integrity of the glomerular filtration barrier. Upregulated transforming growth factor β (TGF-β) and altered
Nina Sopel   +3 more
doaj   +1 more source

The Love-Hate Relationship Between TGF-β Signaling and the Immune System During Development and Tumorigenesis

open access: yesFrontiers in Immunology, 2022
Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian development and disease, particularly cancer, has constantly been updated.
Baode Chen   +4 more
doaj   +1 more source

TGF-βMERUPAKAN MEDIATOR IMUNOSUPRESI DARI SEL T CD4 + CD25 + IN VITRO

open access: yesJurnal Kedokteran Brawijaya, 2013
Naturally the existency of regulatory T cells are represented by CD4+CD25+T cells. Those cells have been identified as a population of immuno-regulatory T cells, which mediated suppression of CD4+CD25+T cells by cell–cell contact. In the effectors phase the function of CD4+CD25+T regulatory T cells through the involvement of certain suppressive ...
openaire   +2 more sources

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