Results 21 to 30 of about 13,045 (219)

LY6K depletion modulates TGF‐β and EGF signaling

Cancer Medicine, 2023
Background Lymphocyte antigen 6 complex locus K (LY6K), a glycosylphosphatidylinositol‐anchored protein, plays a dynamic role in cancer metastasis.
Sujeong Park, Doyeon Park, Sora Han, Ga Eun Chung, Sujung Soh, Hye In Ka, Hyun Jeong Joo, Young Yang   +7 more
doaj   +1 more source

IGFBP‐3 and TGF‐β inhibit growth in epithelial cells by stimulating type V TGF‐β receptor (TβR‐V)‐mediated tumor suppressor signaling

FASEB BioAdvances, 2021
The TGF‐β type V receptor (TβR‐V) mediates growth inhibition by IGFBP‐3 and TGF‐β in epithelial cells and loss of TβR‐V expression in these cells leads to development of carcinoma.
Chun‐Lin Chen, Franklin W. Huang, Shuan Shian Huang, Jung San Huang   +3 more
doaj   +1 more source

Transforming growth factor-β: Biology and application to cancer therapy [PDF]

Archive of Oncology, 2009
Transforming growth factor-β (TGF-β), an extensively investigated cytokine, plays a very important role in promoting the spread of cancers in the body, and can play a direct role in facilitating metastasis.
Ivanović Vesna
doaj   +1 more source

Autocrine TGF-β Induces Epithelial to Mesenchymal Transition in Human Amniotic Epithelial Cells

Cell Transplantation, 2013
Human amniotic epithelial cells (hAECs) have been the object of intense research due to their potential therapeutic use. In this paper, we present molecular evidence of a bona fide epithelial to mesenchymal transition (EMT) undergone by hAECs.
Antonia Alcaraz, Anna Mrowiec, Carmen L. Insausti, Eva M. García-Vizcaíno, Catalina Ruiz-Canada, María C. López-Martínez, José M. Moraleda, Francisco J. Nicolás   +7 more
doaj   +1 more source

Murine CD4 T cells produce a new form of TGF-β as measured by a newly developed TGF-β bioassay. [PDF]

PLoS ONE, 2011
It is generally assumed that T cells do not produce active TGF-β since active TGF-β as measured in supernatants by ELISA without acidification is usually not detectable. However, it is possible that active TGF-β from T cells may take a special form which
Takatoku Oida, Howard L Weiner
doaj   +1 more source

Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy

Journal for ImmunoTherapy of Cancer, 2023
Background Circulating transforming growth factor-β (TGF-β)-specific T cells that recognize TGF-β-expressing immune regulatory cells have been described in patients with cancer.
Mads Hald Andersen, Özcan Met, Inge Marie Svane, Morten Orebo Holmström, Thomas Landkildehus Lisle, Rasmus Erik Johansson Mortensen, Jane P Hasselby, Gro L Willemoe, Julia Johansen, Dorte L Nielsen, Inna M Chen   +10 more
doaj   +1 more source

TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy

Frontiers in Immunology, 2022
Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes, such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides, TGF-β plays a vital role in diseases, including cancer.
Ming Yi, Ming Yi, Tianye Li, Mengke Niu, Yuze Wu, Zhenyu Zhao, Kongming Wu   +6 more
doaj   +1 more source

Lumican promotes joint fibrosis through TGF‐β signaling

FEBS Open Bio, 2020
Joint contracture (also known as arthrofibrosis) is a fibrotic joint disorder characterized by excessive collagen production to form fibrotic scar tissue and adhesions within joint capsules.
Dahai Xiao, Tangzhao Liang, Ze Zhuang, Ronghan He, Jianhua Ren, Shihai Jiang, Lei Zhu, Kun Wang, Dehai Shi   +8 more
doaj   +1 more source

Editorial Special Issue TGF-Beta/BMP Signaling Pathway

Cells, 2020
The transforming growth factor β (TGF-β) superfamily plays key roles in development and tissue homeostasis, controlling the maintenance and regeneration of mature tissues [...]
Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +2 more
doaj   +1 more source

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy

Advanced Science, 2022
Tendinopathy is a common tendon disorder that causes pain and impairs function. It is the most common reason for consultation with musculoskeletal specialists.
Xiao Wang, Shen Liu, Tao Yu, Senbo An, Ruoxian Deng, Xiaohua Tan, Janet Crane, Weixin Zhang, Dayu Pan, Mei Wan, Andrew Carr, Xu Cao   +11 more
doaj   +1 more source