Results 21 to 30 of about 2,112,620 (360)
THU0271 SERUM LEVELS OF TRANSFORMING GROWTH FACTOR î‘ (TGF-î‘) IN PATIENTS WITH PRIMARY SJÖGREN'S SYNDROME [PDF]
Annals of the Rheumatic Diseases, 2019 Background Primary Sjogren’s syndrome (pSS) is an autoimmune disease affecting primarily exocrine, especially salivary, glands. The epithelial damage, autoantigens release, activation of innate and acquired immunity form the underlaying of the pSS pathogenesis. The main role in pSS is played by B-lymphocytes and production of autoantibodies.
Maria Maślińska +4 more
openaire +1 more source
NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice
Redox Biology, 2021 Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass.
M. Herranz-Itúrbide +11 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Skin wound healing is a physiological process that involves several cell types. Among them, endothelial cells are required for inflammation resolution and neo‐angiogenesis, both necessary for tissue restoration after injury.
Javier Stelling-Férez +6 more
doaj +1 more source
SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
Communications Biology, 2022 In pancreatic ductal adenocarcinoma cells and patient tissue, SMAD2/3 is shown to mediate oncogenic effects of TGF-β in the absence of SMAD4.
Adrien Bertrand-Chapel +21 more
doaj +1 more source
Transforming Growth Factor (TGF) β and Endometrial Vascular Maturation
Frontiers in Cell and Developmental Biology, 2021 Appropriate growth and development of the endometrium across the menstrual cycle is key for a woman’s quality of life and reproductive well-being. Recurrent pregnancy loss (RPL) and heavy menstrual bleeding (HMB) affect a significant proportion of the ...
Qinsheng Lu +7 more
doaj +1 more source
TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Nature, 2018 Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer.
S. Mariathasan +41 more
semanticscholar +1 more source
Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8
Bio-Protocol, 2022 Transforming growth factor beta (TGF-β) is a multi-functional cytokine that plays a significant role in multiple diseases, including fibrosis and tumor progression.
Robert Seed, Stephen Nishimura
doaj +1 more source
Journal of Experimental Medicine, 2003 CD4+CD25+ regulatory T cells (Treg) are instrumental in the maintenance of immunological tolerance. One critical question is whether Treg can only be generated in the thymus or can differentiate from peripheral CD4+CD25− naive T cells.
Wanjun Chen +7 more
semanticscholar +1 more source
Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1. [PDF]
, 2016 TGF-β-induced endothelial-to-mesenchymal transition (EndoMT) is a newly recognized source of profibrotic activated myofibroblasts and has been suggested to play a role in the pathogenesis of various fibrotic processes.
Jimenez, Sergio A. +3 more
core +6 more sources
LY6K depletion modulates TGF‐β and EGF signaling
Cancer Medicine, 2023 Background Lymphocyte antigen 6 complex locus K (LY6K), a glycosylphosphatidylinositol‐anchored protein, plays a dynamic role in cancer metastasis.
Sujeong Park +7 more
doaj +1 more source