Results 11 to 20 of about 2,112,620 (360)
Latent-TGF-β has a domain swapped architecture [PDF]
Nature CommunicationsThe multifunctional cytokine TGF-β is a dimeric protein produced within a latent complex (L-TGF-β). Latency is maintained by disulfide linked homodimeric prodomains forming a ring encircling the non-covalently bound mature TGF-β homodimer.
Mingliang Jin +6 more
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Unraveling the influence of TGF-β rs9282871 and miRNA let-7c relative expression on TGF-β production in hepatocellular carcinoma patients [PDF]
Journal of Genetic Engineering and BiotechnologyHepatocellular carcinoma (HCC) is ranked globally as the second most common cancer-related death. Transforming growth factor beta (TGF-β) plays a dual role in HCC.
Sally Farouk +3 more
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Novel therapies emerging in oncology to target the TGF-β pathway
Journal of Hematology & Oncology, 2021 The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tumor promoter or
Byung-Gyu Kim +4 more
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Frontiers in Bioengineering and Biotechnology, 2021 The application of amniotic membrane (AM) on chronic wounds has proven very effective at resetting wound healing, particularly in re-epithelialization. Historically, several aspects of AM effect on wound healing have been evaluated using cell models.
Catalina Ruiz-Cañada +5 more
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The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease
Cells, 2021 The Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver development and homeostasis and become a relevant factor involved in different liver pathologies, particularly fibrosis and cancer. The family of NADPH oxidases (NOXs) has
Macarena Herranz-Itúrbide +4 more
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Serum TGF-β and TNF-α During Psoriasis Therapy with Narrowband Ultraviolet B [PDF]
American Journal of Applied Sciences, 2014 Although it is now an accepted concept that narrow-band UVB therapy is an efficacious therapy for psoriasis, the relationship between the response rate and the potential effects on serum cytokines is less well-established. The purpose of this study was to investigate the correlation between the response rate and the changes of serum TGF-I² and TNF-I ...
Ahmad Taha Khalaf, Yan Yuehua
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Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma
Redox Biology, 2023 The NADPH oxidase NOX4 has been proposed as necessary for the apoptosis induced by the Transforming Growth Factor-beta (TGF-β) in hepatocytes and hepatocellular carcinoma (HCC) cells.
Rut Espinosa-Sotelo +17 more
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Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective
Cells, 2020 Chronic wounds are characterized for their incapacity to heal within an expected time frame. Potential mechanisms driving this impairment are poorly understood and current hypotheses point to the development of an unbalanced milieu of growth factor and ...
Sergio Liarte +2 more
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Targeting TGF-β signal transduction for fibrosis and cancer therapy
Molecular Cancer, 2022 Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune supervision, tissue repair, and adult homeostasis.
Dandan Peng +4 more
semanticscholar +1 more source
Cells, 2020 Defects in wound closure can be related to the failure of keratinocytes to re-epithelize. Potential mechanisms driving this impairment comprise unbalanced cytokine signaling, including Transforming Growth Factor-β (TFG-β).
Sergio Liarte +2 more
doaj +1 more source