Results 11 to 20 of about 55,562 (295)
Smad3 Signatures in Renal Inflammation and Fibrosis
International Journal of Biological Sciences, 2022 Renal inflammation and fibrosis are key pathological features of acute kidney injury (AKI) and chronic kidney disease (CKD). Smad3 is a critical mediator of TGF-β signaling and plays a pathogenic role in both renal inflammation and fibrosis. Smad3 can be
Wenjing Wu +3 more
semanticscholar +3 more sources
BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses. [PDF]
PLoS ONE, 2009 BRCA1 is a key regulatory protein participating in cell cycle checkpoint and DNA damage repair networks. BRCA1 plays important roles in protecting numerous cellular processes in response to cell damaging signals. Transforming growth factor-beta (TGF-beta)
Huchun Li +4 more
doaj +4 more sources
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Nature Communications, 2023 TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and
J. Chung +14 more
semanticscholar +1 more source
Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition
Advancement of science, 2021 Cancer‐associated fibroblasts (CAFs) are important in tumor microenvironment (TME) driven cancer progression. However, CAFs are heterogeneous and still largely underdefined, better understanding their origins will identify new therapeutic strategies for ...
P. Tang +15 more
semanticscholar +1 more source
Molecular Cancer, 2023 Background Among digestive tract tumours, pancreatic ductal adenocarcinoma (PDAC) shows the highest mortality trend. Moreover, although PDAC metastasis remains a leading cause of cancer-related deaths, the biological mechanism is poorly understood ...
Zhongjie Zhao +17 more
semanticscholar +1 more source
SMAD3 promotes expression and activity of the androgen receptor in prostate cancer
Nucleic Acids Research, 2023 Overexpression of androgen receptor (AR) is the primary cause of castration-resistant prostate cancer, although mechanisms upregulating AR transcription in this context are not well understood.
H. Jeon +15 more
semanticscholar +1 more source
The Endogenous Ratio of Smad2 and Smad3 Influences the Cytostatic Function of Smad3 [PDF]
Molecular Biology of the Cell, 2005 Although Smad2 and Smad3, critical transcriptional mediators of transforming growth factor-β (TGF-β) signaling, are supposed to play a role in the TGF-β cytostatic program, it remains unclear whether TGF-β delivers cytostatic signals through both Smads equally or through either differentially.
Sang Gyun, Kim +7 more
openaire +2 more sources
Haseki Tıp Bülteni, 2022 Loeys-Dietz syndrome (LDS) is a rare autosomal dominant connective tissue disorder with multisystemic involvement caused by pathogenic genetic variations in the transforming growth factor- β pathway. Here, we report a homozygous case with LDS.
Betul Okur Altindas +4 more
doaj +1 more source
Journal of Vascular Surgery Cases and Innovative Techniques, 2021 Loeys-Dietz syndrome (LDS) type 3 results from a SMAD3 mutation and is a phenotypically milder variant of LDS with frequent aortic, visceral, and cerebral vascular pathologies and osteoarthritis.
Kirthi S. Bellamkonda, MSc +2 more
doaj +1 more source
Journal of Hematology & Oncology, 2022 Background Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, the roles of long noncoding RNAs (lncRNAs) hijacked by super-enhancers (SEs), vital regulatory elements of the epigenome, remain elusive in the progression of LUAD ...
Te Zhang +14 more
semanticscholar +1 more source