Results 31 to 40 of about 55,562 (295)

Expression of Nodal, Cripto, SMAD3, Phosphorylated SMAD3, and SMAD4 in the Proliferative Endometrium of Women With Endometriosis [PDF]

Reproductive Sciences, 2015
Nodal is a growth factor of the transforming growth factor β superfamily that is expressed in high turnover tissues, such as the human endometrium, and in several malignancies. The effects of Nodal are modulated by the coreceptor Cripto and mediated by SMAD proteins.
Cruz, Cynthia Dela, Del Puerto, Helen L., Rocha, Ana Luiza L., Cavallo, InÃas K., Clarizia, Alessandra D., Petraglia, Felice, Reis, Fernando M.   +6 more
openaire   +3 more sources

Validation studies for germ-free Smad3-/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD

Gut Microbes, 2020
While the association between microbiomes and inflammatory bowel disease (IBD) is well known, establishing causal relationships between the two is difficult in humans. Germ-free (GF) mice genetically susceptible to IBD can address this question. Smad3-/-
Jisun Paik, Stacey Meeker, Charlie C. Hsu, Audrey Seamons, Olesya Pershutkina, Jessica M. Snyder, Thea Brabb, Lillian Maggio-Price   +7 more
doaj   +1 more source

Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression

Theranostics, 2021
Rationale: Transforming Growth Factor-beta (TGF-β) /Smad3 signaling has been shown to play important roles in fibrotic and inflammatory diseases, but its role in beta cell function and type 2 diabetes is unknown.
Jingyi Sheng, Li Wang, P. Tang, Honglian Wang, Jianchun Li, Bi-Hua Xu, V. Xue, R. Tan, Nana Jin, T. Chan, Xiao-ru Huang, R. C. Ma, H. Lan   +12 more
semanticscholar   +1 more source

Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3

FEBS Open Bio, 2020
Smad3 signaling and transgelin expression are often activated during puromycin aminonucleoside (PAN)‐induced podocyte injury. Here, we investigated whether the Smad3 inhibitor SIS3 can ameliorate damage to injured podocytes.
Lina Jiang, Hong Cui, Jie Ding, Aijun Yang, Yingchao Zhang   +4 more
doaj   +1 more source

Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas

OncoTargets and Therapy, 2016
Transforming growth factor-β (TGF-β) signaling plays important roles in tumor development. Nevertheless, the roles of TGF-β/Smad signaling in nonfunctioning pituitary adenomas (NFPAs) have not been fully studied.Tumor samples were obtained from patients who had NFPAs and underwent endoscopic transsphenoidal surgery or craniotomy at Beijing Tiantan ...
Liu,Chunhui, Li,Zhenye, Wu,Dan, Li,Chuzhong, Zhang,Yazhuo   +4 more
openaire   +4 more sources

Two Short Segments of Smad3 Are Important for Specific Interaction of Smad3 with c-Ski and SnoN [PDF]

Journal of Biological Chemistry, 2003
c-Ski and SnoN are transcriptional co-repressors that inhibit transforming growth factor-beta signaling through interaction with Smad proteins. Among receptor-regulated Smads, c-Ski and SnoN bind more strongly to Smad2 and Smad3 than to Smad1. Here, we show that c-Ski and SnoN bind to the "SE" sequence in the C-terminal MH2 domain of Smad3, which is ...
Masafumi, Mizuide, Takane, Hara, Toshio, Furuya, Masafumi, Takeda, Kiyoshi, Kusanagi, Yuri, Inada, Masatomo, Mori, Takeshi, Imamura, Keiji, Miyazawa, Kohei, Miyazono   +9 more
openaire   +2 more sources

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Cells, 2020
The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang   +7 more
doaj   +1 more source

Pirfenidone modulates macrophage polarization and ameliorates radiation‐induced lung fibrosis by inhibiting the TGF‐β1/Smad3 pathway

Journal of Cellular and Molecular Medicine, 2020
Radiation‐induced lung injury (RILI) mainly contributes to the complications of thoracic radiotherapy. RILI can be divided into radiation pneumonia (RP) and radiation‐induced lung fibrosis (RILF).
H. Ying, M. Fang, Q. Hang, Yamei Chen, Xu Qian, Ming Chen   +5 more
semanticscholar   +1 more source

miR-665 inhibits epithelial-to-mesenchymal transition in bladder cancer via the SMAD3/SNAIL axis

Cell Cycle, 2021
Emerging research indicates that miRNAs can regulate cancer progression by influencing molecular pathways. Here, we studied miR-665, part of the DLK1-DIO3 miRNA cluster, which is downregulated by upstream methylation in bladder cancer.
Weiyu Wang, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xueyou Ma, Liujia He, Mingjie Xu, Shiming Chen, Haixiang Shen, Xiangyi Zheng, Ben Liu, Xiao Wang, Liping Xie   +12 more
semanticscholar   +1 more source

FOXO1 Negates the Cooperative Action of FOXL2C134W and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3 [PDF]

Journal of the Endocrine Society, 2019
AbstractAdult granulosa cell tumor (aGCT) is a rare type of ovarian cancer characterized by estrogen excess. Interestingly, only the single somatic mutation FOXL2C134W was found across virtually all aGCTs. We previously reported that FOXL2C134W stimulates CYP19 transcription synergistically with SMAD3, leading to elevated estradiol synthesis in a human
Martina Belli, Christian Secchi, Dwayne Stupack, Shunichi Shimasaki   +3 more
openaire   +4 more sources