Results 51 to 60 of about 55,562 (295)

Hypoxia-activated Smad3-specific Dephosphorylation by PP2A [PDF]

Journal of Biological Chemistry, 2010
The transforming growth factor-beta (TGF-beta) maintains epithelial homeostasis and suppresses early tumor formation, but paradoxically at later stages of tumor progression, TGF-beta promotes malignancy. TGF-beta activates phosphorylation of Smad2 and -3 effectors. Smad2 and -3 are known to have different functions, but differential regulation of their
Heikkinen, PT, Nummela, M, Leivonen, SK, Westermarck, J, Hill, CS, K\303\244h\303\244ri VM, Jaakkola, PM   +6 more
openaire   +3 more sources

Phospho-specific Smad3 signaling [PDF]

Cell Cycle, 2012
Members of the TGFβ superfamily are known to exert a myriad of physiologic and pathologic growth controlling influences on mammary development and oncogenesis. In epithelial cells, TGFβ signaling inhibits cell growth through cytostatic and pro-apoptotic activities but can also induce cancer cell EMT and, thus, has a dichotomous role in breast cancer ...
Elizabeth, Tarasewicz, Jacqueline S, Jeruss   +1 more
openaire   +2 more sources

Identification and validation of transcriptome-wide association study-derived genes as potential druggable targets for osteoarthritis

Bone & Joint Research
Aims: Osteoarthritis (OA) is a widespread chronic degenerative joint disease with an increasing global impact. The pathogenesis of OA involves complex interactions between genetic and environmental factors.
Xindie Zhou, Xinjian Ye, Jiapei Yao, Xiaolong Lin, Yiping Weng, Yong Huang, Yaojun Lu, JingJing Shang, Luming Nong   +8 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

TGF-β-Induced TMEPAI Promotes Epithelial–Mesenchymal Transition in Doxorubicin-Treated Triple-Negative Breast Cancer Cells via SMAD3 and PI3K/AKT Pathway Alteration

Breast Cancer: Targets and Therapy, 2021
Bantari WK Wardhani,1,2 Melva Louisa,3 Yukihide Watanabe,4 Rianto Setiabudy,3 Mitsuyasu Kato4 1Biomedical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; 2Department of Pharmacology, Faculty of Military Pharmacy, Indonesia ...
Wardhani BWK, Louisa M, Watanabe Y, Setiabudy R, Kato M   +4 more
doaj  

Parabolic relationship between SMAD3 expression level and the reprogramming efficiency of goat induced mammary epithelial cells

Frontiers in Cell and Developmental Biology, 2022
Mammary epithelial cells are the only cells of mammary glands with lactation capacity. They are closely related to mammary development and milk yield. Our earlier studies showed that the transformation of goat fibroblasts into induced mammary epithelial ...
Yulian Wu, Yulian Wu, Yulian Wu, Dandan Zhang, Sheng Ye, Sheng Ye, Quanhui Liu, Quanhui Liu, Ben Huang, Ben Huang, Ben Huang   +10 more
doaj   +1 more source

Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation

Circulation Research, 2019
Rationale: Transforming Growth Factor (TGF)-β is critically involved in myocardial injury, repair and fibrosis, activating both Smad-dependent and non-Smad pathways.
Bijun Chen, Shuaibo Huang, Ya Su, Yi-Jin Wu, Anis Hanna, Adipong Brickshawana, J. Graff, N. Frangogiannis   +7 more
semanticscholar   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways

World Journal of Gastroenterology, 2017
To study the molecular mechanisms involved in the hepatoprotective effects of naringenin (NAR) on carbon tetrachloride (CCl4)-induced liver fibrosis.Thirty-two male Wistar rats (120-150 g) were randomly divided into four groups: (1) a control group (n = 8) that received 0.7% carboxy methyl-cellulose (NAR vehicle) 1 mL/daily p.o.; (2) a CCl4 group (n ...
Hernández-Aquino, Erika, Zarco, Natanael, Casas-Grajales, Sael, Ramos-Tovar, Erika, Flores-Beltrán, Rosa E, Arauz, Jonathan, Shibayama, Mineko, Favari, Liliana, Tsutsumi, Víctor, Segovia, José, Muriel, Pablo   +10 more
openaire   +2 more sources

Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling

Cell Death and Disease, 2020
Prevailing insulin resistance and the resultant hyperglycemia elicits a compensatory response from pancreatic islet beta cells (β-cells) that involves increases in β-cell function and β-cell mass.
Jihyeon Lee, J. Mellado-Gil, Y. Bahn, Sushrut M. Pathy, Ying E. Zhang, S. Rane   +5 more
semanticscholar   +1 more source