Results 71 to 80 of about 55,562 (295)

CRISPR screens identify tumor‐promoting genes conferring melanoma cell plasticity and resistance

EMBO Molecular Medicine, 2021
Most genetic alterations that drive melanoma development and resistance to targeted therapy have been uncovered. In contrast, and despite their increasingly recognized contribution, little is known about the non‐genetic mechanisms that drive these ...
Arthur Gautron, Laura Bachelot, Marc Aubry, Delphine Leclerc, Anaïs M Quéméner, Sébastien Corre, Florian Rambow, Anaïs Paris, Nina Tardif, Héloïse M Leclair, Oskar Marin‐Bejar, Cédric Coulouarn, Jean‐Christophe Marine, Marie‐Dominique Galibert, David Gilot   +14 more
doaj   +1 more source

HCP5 is a SMAD3-responsive long non-coding RNA that promotes lung adenocarcinoma metastasis via miR-203/SNAI axis

Theranostics, 2019
Introduction: Transforming growth factor-beta (TGFβ) signaling plays a vital role in lung adenocarcinoma (LUAD) progression. However, the involvement of TGFβ-regulated long non-coding RNAs (lncRNAs) in metastasis of LUAD remains poorly understood ...
Lin Jiang, Ranran Wang, Li Fang, Xiaolu Ge, Lingna Chen, Ming Zhou, Yanhong Zhou, W. Xiong, Yerong Hu, Xianmin Tang, Gui-yuan Li, Zheng Li   +11 more
semanticscholar   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

EWSR1-SMAD3 positive fibroblastic tumor

Experimental and Molecular Pathology, 2019
We present a case of EWSR1-SMAD3 positive fibroblastic tumor that occurred in a 24-year-old man who presented with a recurrent tumor in the dorsum of his right foot. Magnetic resonance imaging (MRI) demonstrated a subcutaneous nodule located in the third metatarsophalangeal joint region, measuring 10 × 8 × 5 mm in size.
Lu, Zhao, Meng, Sun, I Weng, Lao, Lin, Yu, Jian, Wang   +4 more
openaire   +2 more sources

Identification and Expression Characterization of the Smad3 Gene and SNPs Associated with Growth Traits in the Hard Clam (Meretrix meretrix)

Fishes, 2021
It has been demonstrated that the sekelsky mothers against decapentaplegic homolog 3 (Smad3) plays an important role in the growth and development of vertebrates. However, little is known about the association between the Smad3 gene and the growth traits
Lulu Fu, Qiudie Chi, Yongbo Bao, Hanhan Yao, Zhihua Lin, Yinghui Dong   +5 more
doaj   +1 more source

LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling

bioRxiv, 2020
Transforming Growth Factor β (TGF-β)-induced fibroblast activation is a key pathological event during tissue fibrosis. Long noncoding RNA (lncRNA) is a class of versatile gene regulators participating in various cellular and molecular processes. However,
Rui Tang, Yung-Chun Wang, Xiaohan Mei, Ning Shi, Chengming Sun, Ran Ran, Gui Zhang, Wenjing Li, K. Staveley-O’Carroll, Guangfu Li, Shiyou Chen   +10 more
semanticscholar   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Low-dose paclitaxel ameliorates pulmonary fibrosis by suppressing TGF-β1/Smad3 pathway via miR-140 upregulation. [PDF]

PLoS ONE, 2013
Abnormal TGF-β1/Smad3 activation plays an important role in the pathogenesis of pulmonary fibrosis, which can be prevented by paclitaxel (PTX). This study aimed to investigate an antifibrotic effect of the low-dose PTX (10 to 50 nM in vitro, and 0.6 mg ...
Congjie Wang, Xiaodong Song, Youjie Li, Fang Han, Shuyan Gao, Xiaozhi Wang, Shuyang Xie, Changjun Lv   +7 more
doaj   +1 more source

Qishen granule attenuates cardiac fibrosis by regulating TGF-β /Smad3 and GSK-3β pathway.

Phytomedicine, 2019
BACKGROUND Cardiac fibrosis is a common pathological progress of cardiovascular disease resulting from the excessive accumulation of extracellular matrix (ECM).
Zifan Zeng, Qiyan Wang, Xiaomin Yang, Yinglu Ren, Shihong Jiao, Qingqing Zhu, Dongqing Guo, Kai Xia, Yong Wang, Chun Li, Wei Wang   +10 more
semanticscholar   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source