Results 81 to 90 of about 55,562 (295)

Loss of Smad3 modulates wound healing

Cytokine & Growth Factor Reviews, 2000
TGF-beta plays a central and critical role in tissue repair. The recent identification of TGF-beta signal transduction pathways involving Smad proteins has now made it possible to explore their contribution to the activities of TGF-beta in vivo. Both Smad3 and its closely related homolog Smad2 act as latent nuclear transcriptional activators and ...
Ashcroft, GS, Roberts, AB
openaire   +2 more sources

Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity [PDF]

Nature Communications, 2017
AbstractRegulatory T (Treg) cells are important for the maintenance of immune homoeostasis and prevention of autoimmune diseases. Epigenetic modifications have been reported to modulate autoimmunity by altering Treg cell fate. Here we show that the H3K4 methyltransferase Ash1l facilitates TGF-β-induced Treg cell polarization in vitro and protects mice ...
Meng Xia, Juan Liu, Shuxun Liu, Kun Chen, Hongyu Lin, Minghong Jiang, Xiaoqing Xu, Yiquan Xue, Wei Liu, Yan Gu, Xiang Zhang, Zhiqing Li, Lin Yi, Youcun Qian, Chen Zhou, Ru Li, Xuan Zhang, Zhanguo Li, Xuetao Cao   +18 more
openaire   +3 more sources

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Mutation analysis of the Smad3 gene in human osteoarthritis [PDF]

European Journal of Human Genetics, 2003
Osteoarthritis (OA) is the most common joint disease worldwide. Recent studies have shown that targeted disruption of Smad3 in mouse results in OA. To reveal the possible association between the Smad3 gene mutation and human OA, we employed polymerase chain reaction-single strand conformation polymorphism and sequencing to screen mutations in all nine ...
Jun-Yan, Yao, Yan, Wang, Jing, An, Chun-Ming, Mao, Ning, Hou, Ya-Xin, Lv, You-Liang, Wang, Fang, Cui, Min, Huang, Xiao, Yang   +9 more
openaire   +2 more sources

Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling

EBioMedicine, 2016
Aneurysm-osteoarthritis syndrome characterized by unpredictable aortic aneurysm formation, is caused by SMAD3 mutations. SMAD3 is part of the SMAD2/3/4 transcription factor, essential for TGF-β-activated transcription.
I. van der Pluijm, PhD, N. van Vliet, BSc, J.H. von der Thusen, PhD, J.L. Robertus, PhD, Y. Ridwan, BSc, P.M. van Heijningen, BSc, B.S. van Thiel, MSc, M. Vermeij, BSc, S.E. Hoeks, PhD, R.M.G.B. Buijs-Offerman, PhD, H.J.M. Verhagen, MD, PhD, R. Kanaar, PhD, A.M. Bertoli-Avella, MD, PhD, J. Essers, PhD   +13 more
doaj   +1 more source

In vitro lineage-specific differentiation of vascular smooth muscle cells in response to SMAD3 deficiency: Implications for SMAD3-related thoracic aortic aneurysm

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: SMAD3 pathogenic variants are associated with the development of thoracic aortic aneurysms. We sought to determine the role of SMAD3 in lineage-specific vascular smooth muscle cells (VSMCs)
Jian Gong, Dong Zhou, Longtan Jiang, P. Qiu, D. Milewicz, Y. Eugene Chen, Bo Yang   +6 more
semanticscholar   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Smad3 activates the Sox9-dependent transcription on chromatin [PDF]

The International Journal of Biochemistry & Cell Biology, 2009
Transforming growth factor (TGF)-beta has an essential role for the Sry-type high-mobility-group box (Sox)-regulated chondrogenesis. Chondrogenic differentiation is also controlled by chromatin-mediated transcription. We have previously reported that TGF-beta-regulated Smad3 induces chondrogenesis through the activation of Sox9-dependent transcription.
Furumatsu, Takayuki, Ozaki, Toshifumi, Asahara, Hiroshi   +2 more
openaire   +3 more sources

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

Genes & Development, 2019
In this study, Aragon et al. set out to address how signal-driven SMAD transcription factors activate differentiation genes. Their results support a model in which signal-independent binding of SMAD3 and FOXH1 prime mesendoderm differentiation gene ...
E. Aragón, Qiong Wang, Y. Zou, Sophie M. Morgani, Lidia Ruiz, Z. Kaczmarska, Jie Su, C. Torner, Lin Tian, Jing Hu, Weiping Shu, Saloni Agrawal, Tiago Gomes, J. Márquez, A. Hadjantonakis, M. Macias, J. Massagué   +16 more
semanticscholar   +1 more source