Results 11 to 20 of about 77,825 (245)
Clinical and Experimental Obstetrics & Gynecology, 2021 Objective: The purpose of this study was to investigate the role of fibulin-5 in the transforming growth factor beta (TGF-β)/Smad signaling pathway by measuring the differential expression of fibulin-5, TGF-β, and Smad2/3 in the connective tissue of the ...
Shaadaiti Wufuer +4 more
doaj +2 more sources
JCI Insight, 2023 TGF-β signaling is crucial for modulating osteoarthritis (OA), and protein phosphatase magnesium–dependent 1A (PPM1A) has been reported as a phosphatase of SMAD2 and regulates TGF-β signaling, while the role of PPM1A in cartilage homeostasis and OA ...
Qinwen Ge +13 more
doaj +3 more sources
MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein. [PDF]
Oncol Rep, 2021 Breast cancer (BC) is one of the most common malignant tumours in women. The matrix metalloproteinase (MMP) enzyme family plays a complex role in the development of BC. There is increasing evidence that MMP11 plays a major role in BC; however, the underlying mechanisms are not clear.
Zhuang Y, Li X, Zhan P, Pi G, Wen G.
europepmc +4 more sources
The regulatory protein SnoN antagonizes activin/Smad2 protein signaling and thereby promotes adipocyte differentiation and obesity in mice. [PDF]
J Biol Chem, 2018 Ski-related oncogene SnoN (SnoN or SKIL) regulates multiple signaling pathways in a tissue- and developmental stage-dependent manner and has broad functions in embryonic angiogenesis, mammary gland alveologenesis, cancer, and aging. Here, we report that SnoN also plays a critical role in white adipose tissue (WAT) development by regulating mesenchymal ...
Zhu Q, Chang A, Xu A, Luo K.
europepmc +7 more sources
An N-terminally truncated Smad2 protein can partially compensate for loss of full-length Smad2 [PDF]
Biochemical Journal, 2008 TGFβ (transforming growth factor β) superfamily signalling is critical both for early embryonic development and later for tissue homoeostasis in adult organisms. The use of gene-disruption techniques in mice has been essential to understanding the functional roles of the components of the pathways downstream of TGFβ superfamily ligands, in particular ...
Das, Debipriya +2 more
openaire +3 more sources
Identification of novel Smad2 and Smad3 associated proteins in response to TGF‐β1 [PDF]
Journal of Cellular Biochemistry, 2008 AbstractTransforming growth factor‐beta 1 (TGF‐β1) is an important growth inhibitor of epithelial cells and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. TGF‐β1 signals through the TGF‐β type I and type II receptors, and activates the Smad pathway via phosphorylation of Smad2 and Smad3 ...
Kimberly A, Brown +8 more
openaire +2 more sources
Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy [PDF]
Journal of Biological Chemistry, 2016 Skeletal muscle atrophy promotes muscle weakness, limiting activities of daily living. However, mechanisms underlying atrophy remain unclear. Here, we show that skeletal muscle immobilization elevates Smad2/3 protein but not mRNA levels in muscle, promoting atrophy.
Toshimi, Tando +19 more
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The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling [PDF]
Cerebral Cortex, 2017 KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early postnatal stages to adulthood and being downregulated by injury. This suggested that KIAA0319 participates
Franquinho, F +9 more
openaire +3 more sources
Involvement of Rho-associated coiled-coil kinase signaling inhibition in TGF-β1/Smad2, 3 signal transduction in vitro [PDF]
International Journal of Ophthalmology, 2017 AIM: To research the effect of Y-27632, a selective Rho-associated coiled-coil kinase (ROCK) inhibitor, on TGF-β1/Smad2, 3 signal transduction in ocular Tenon’s capsule fibroblasts (OTFs).
Zhao-Hui Feng +3 more
doaj +1 more source
miR-9500 Regulates Migration and Invasion of Lung Adenocarcinoma Cells by Targeting SMAD2
Zhongliu Fangzhi Yanjiu, 2023 Objective To explore the molecular mechanism underlying miR-9500 regulating the migration and invasion of lung adenocarcinoma cells by targeting SMAD2. Methods The core target genes of miR-9500 were screened out by bioinformatics analysis, and their GO ...
LI Fang, HAN Caili, WANG Li, SHEN Hui
doaj +1 more source