Results 21 to 30 of about 77,825 (245)
Journal of Cellular Physiology, 2006 AbstractThe endothelial nitric oxide synthase (eNOS) is a critical regulator of cardiovascular homeostasis, whose dysregulation leads to different vascular pathologies. Endoglin is a component of the transforming growth factor beta (TGF‐β) receptor complex present in endothelial cells that is involved in angiogenesis, cardiovascular development, and ...
Santibanez, Juan F. +8 more
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ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN [PDF]
Journal of Cell Science, 2011 SARA, an early endosomal protein, plays a key role in TGFβ signalling, as it presents SMAD2 and SMAD3 for phosphorylation by the activated TGFβ receptors. Here, we show that ERBIN is a new SARA-interacting protein that can be recruited by SARA to early endosomes. ERBIN was recently shown to bind and segregate phosphorylated SMAD2 and SMAD3 (SMAD2/3) in
Sflomos, Georgios +7 more
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Neuroprotective effects of SMADs in a rat model of cerebral ischemia/reperfusion
Neural Regeneration Research, 2015 Previous studies have shown that up-regulation of transforming growth factor β1 results in neuroprotective effects. However, the role of the transforming growth factor β1 downstream molecule, SMAD2/3, following ischemia/reperfusion remains unclear. Here,
Fang-fang Liu +6 more
doaj +1 more source
Frontiers in Endocrinology, 2022 The acquisition of an endovascular trophoblast (enEVT) phenotype is essential for normal placental development and healthy pregnancy. MicroRNAs (miRNAs) are small noncoding RNAs that play critical roles in regulating gene expression.
Yanan Shan +6 more
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Molecular Medicine, 2023 Background Epithelial–mesenchymal transition (EMT) plays a key role in tubulointerstitial fibrosis, which is a hallmark of diabetic kidney disease (DKD).
Yujie Li +8 more
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miR-425-5p targets TGF-β1/Smad2 signaling pathway to attenuate collagen fiber deposition in hypertrophic scar tissue in mice [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the role and mechanism of miR-425-5p in the formation of hypertrophic scar(HS).Methods The levels of miR-425-5p, transforming growth factor-β1 (TGF-β1) and SMAD family member 2 (Smad2) in 16 pairs of HS tissue and normal skin ...
LIANG Yan, WANG Lijuan, WU Huilin
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Sirt1 interaction with active Smad2 modulates transforming growth factor-β regulated transcription
Cell Communication and Signaling, 2017 Background The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses.
Eva María García-Vizcaíno +3 more
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BMC Complementary and Alternative Medicine, 2018 Background This study was to evaluate the effects of herbal compound 861 (Cpd861) on ski-related novel protein N (SnoN) and transforming growth factor-β1 (TGF-β1) /Smad signaling in rats with bile duct ligation (BDL)-induced hepatic fibrosis, and to ...
Cheng Chi +7 more
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Identification of Smad2, a Human Mad-related Protein in the Transforming Growth Factor β Signaling Pathway [PDF]
Journal of Biological Chemistry, 1997 Transforming growth factor-beta (TGF-beta) superfamily members are multifunctional cytokines that exert their effects via heteromeric complexes of two distinct serine and threonine kinase receptors. Drosophila mothers against decapentaplegic and related genes in Caenorhabditis elegans, Xenopus, and mammals were shown to function downstream in the ...
A, Nakao +6 more
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PLoS ONE, 2009 The Transforming Growth Factor (TGF) beta signalling family includes morphogens, such as Nodal and Activin, with important functions in vertebrate development.
Marcela Guzman-Ayala +5 more
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