Results 31 to 40 of about 77,825 (245)

TRPV1 potentiates TGFβ-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop. [PDF]

PLoS ONE, 2013
Injuring mouse corneas with alkali causes myofibroblast expression leading to tissue opacification. However, in transient receptor potential vanilloid 1 channel (TRPV1-/-) knockout mice healing results in transparency restoration.
Yuanquan Yang, Zheng Wang, Hua Yang, Lingyan Wang, Stephanie R Gillespie, J Mario Wolosin, Audrey M Bernstein, Peter S Reinach   +7 more
doaj   +1 more source

miR-155 inhibits chondrocyte pyroptosis in knee osteoarthritis by targeting SMAD2 and inhibiting the NLRP3/Caspase-1 pathway

Journal of Orthopaedic Surgery and Research, 2022
Objective Knee osteoarthritis (KOA) is based on degenerative pathological changes. miR-155 is involved in regulating KOA. This study estimated the mechanism of miR-155 in mouse KOA chondrocytes.
Gen Li, Lijun Xiu, Xiaoyun Li, Lisha Ma, Jihui Zhou   +4 more
doaj   +1 more source

Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

Frontiers in Pharmacology, 2017
Aims: Chlorogenic acid (CGA) is a phenolic acid that has a wide range of pharmacological effects. However, the protective effects and mechanisms of CGA on liver fibrosis are not clear.
Fan Yang, Lei Luo, Zhi-De Zhu, Xuan Zhou, Yao Wang, Juan Xue, Juan Zhang, Xin Cai, Zhi-Lin Chen, Qian Ma, Yun-Fei Chen, Yu-Jie Wang, Ying-Ying Luo, Pan Liu, Lei Zhao   +14 more
doaj   +1 more source

Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer

Molecular Medicine, 2023
Abstract Background Colorectal cancer (CRC) is the third frequently diagnosed cancer with high incidence and mortality rate worldwide. Our previous report has demonstrated that circCOL1A1 (hsa_circ_0044556) functions as an oncogene in CRC, and Gene Ontology (GO) analysis has also revealed the strong association between ...
Gui Hu, Changwei Lin, Kai Gao, Miao Chen, Fei Long, Buning Tian   +5 more
openaire   +3 more sources

Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background SMAD2 is a coregulator that binds a variety of transcription factors in human development. Heterozygous SMAD2 loss‐of‐function and missense variants are identified in patients with congenital heart disease (CHD) or arterial aneurysms ...
Tarsha Ward, Sarah U. Morton, Gabriela Venturini, Warren Tai, Min Young Jang, Joshua Gorham, Dan Delaughter, Lauren K. Wasson, Zahra Khazal, Jason Homsy, Bruce D. Gelb, Wendy K. Chung, Benoit G. Bruneau, Martina Brueckner, Martin Tristani‐Firouzi, Steven R. DePalma, Christine Seidman, J. G. Seidman   +17 more
doaj   +1 more source

Mechanism of miR-15a regulating the growth and apoptosis of human knee joint chondrocytes by targeting SMAD2

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Objective To investigate the effects of miR-15a on proliferation and apoptosis of human knee articular chondrocytes and explore its underlying mechanism.Methods qRT-PCR was used to detect the expression of miR-15a in normal chondrocytes and knee ...
Tengjun Ma, Yan Cheng, Liang Tan
doaj   +1 more source

Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis

Frontiers in Pharmacology, 2023
Background: Gastrodin has been widely used clinically in China as an antihypertensive drug. However, its effect on hypertensive renal injury is yet to be elucidated.
Ying Wen, Ying Wen, Ying Wen, Xiuli Zhang, Xiuli Zhang, Xiuli Zhang, Lihui Wei, Lihui Wei, Lihui Wei, Lihui Wei, Meizhu Wu, Meizhu Wu, Meizhu Wu, Ying Cheng, Ying Cheng, Ying Cheng, Huifang Zheng, Huifang Zheng, Huifang Zheng, Aling Shen, Aling Shen, Aling Shen, Aling Shen, Changgeng Fu, Changgeng Fu, Farman Ali, Farman Ali, Farman Ali, Linzi Long, Linzi Long, Yao Lu, Yao Lu, Yao Lu, Jiapeng Li, Jun Peng, Jun Peng, Jun Peng   +36 more
doaj   +1 more source

Activin A Signaling Induces Smad2, but Not Smad3, Requiring Protein Kinase A Activity in Granulosa Cells from the Avian Ovary [PDF]

Journal of Biological Chemistry, 2003
Activin A signaling is an important regulator of ovarian granulosa cell function. The cytosolic signal transducer Smad2 is most highly expressed in chicken granulosa cells (cGC) of preovulatory follicles. Moreover, Smad2 shows predominant nuclear localization in freshly isolated cGC, indicating active Smad signaling in vivo.
Bernhard, Schmierer, Michael K, Schuster, Alena, Shkumatava, Karl, Kuchler   +3 more
openaire   +2 more sources

The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activatedwnt8aExpression [PDF]

The Journal of Neuroscience, 2015
During vertebrate embryogenesis, the neuroectoderm is induced from dorsal ectoderm and then partitioned into anterior and posterior neuroectodermal domains by posteriorizing signals, such as Wnt and fibroblast growth factor. However, little is known about epigenetic regulation of posteriorizing gene expression.
Yuanqing, Ma, Xiuli, Liu, Zhaoting, Liu, Shi, Wei, Hanqiao, Shang, Yu, Xue, Yu, Cao, Anming, Meng, Qiang, Wang   +8 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source