Results 51 to 60 of about 1,414,547 (185)
Upregulation of TRPM3 in nociceptors innervating inflamed tissue
eLife, 2020 Genetic ablation or pharmacological inhibition of the heat-activated cation channel TRPM3 alleviates inflammatory heat hyperalgesia, but the underlying mechanisms are unknown.
Marie Mulier +7 more
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TRPA1 expression and its functional activation in rodent cortex [PDF]
Open Biology, 2017 TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here,
Ehsan Kheradpezhouh +3 more
doaj +1 more source
Geographical Variation in Thermal Adaptation of the Asiatic Toad (Bufo gargarizans)
Integrative Zoology, EarlyView.Northern and southern populations of Bufo gargarizans exhibit coordinated divergence in thermal preference, resting metabolic rate, and TRPM4 temperature sensitivity along a climatic gradient. ABSTRACT Thermal adaptation in animals can manifest in multiple dimensions, yet few studies have integrated behavioral, physiological, and molecular perspectives
Longcheng Fan, Yonghua Wu
wiley +1 more source
Pore dilation occurs in TRPA1 but not in TRPM8 channels
Molecular Pain, 2009 Abundantly expressed in pain-sensing neurons, TRPV1, TRPA1 and TRPM8 are major cellular sensors of thermal, chemical and mechanical stimuli. The function of these ion channels has been attributed to their selective permeation of small cations (e.g., Ca2+,
Faltynek Connie R +6 more
doaj +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Neurophysiological and histopathological evaluation of small fiber pathways as diagnostic characterization of neuropathic pain and autonom dysfunction syndromes [PDF]
, 2012 This manuscript is made up of two individual not related articles about peripheral neuropathic pain syndrome. The first article reports the effect on pain relief in patients with peripheral neuropathic pain after brachial plexus lesions or distal ...
Devigli, Grazia, Devigili, Grazia
core
Frontiers in Physiology, 2016 The transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is conserved between many arthropods, and in some has been shown to function as a chemosensor for noxious compounds.
Guangda Peng +5 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]
, 2007 Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B +11 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source