Results 71 to 80 of about 5,960 (158)

Urinary Lipid Production Profile of Patients With Food Allergy

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko, Shinichiro Inagaki, Taiki Hamabata, Takeru Ishii, Nanae Nagata, Kiwako Yamamoto‐Hanada, Tatsuki Fukuie, Masami Narita, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata   +10 more
wiley   +1 more source

Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post‐Traumatic Trigeminal Neuropathic Pain: A Real‐World Evidence Study

Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1550-1561, August 2026.
A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel, Imen Stambouli, Yves Boucher   +2 more
wiley   +1 more source

Strategies for the Selection and Application of Biological Scaffolds in Organ‐on‐a‐Chip Systems

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Organ‐on‐a‐chip (OoC) serves as a promising microphysiological platform for drug screening, disease modeling, and toxicity assessment. Biomimetic scaffolds are core components that determine the performance of OoC systems by mimicking the in vivo extracellular microenvironment.
Yichi Zhang, Ning Zhang, Linkai Jiang, Zhilong Zhou, Yuwei Zhang, Yuwen Wang, Yiting Lei, Ning Hu, Zhong Alan Li   +8 more
wiley   +1 more source

Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1

SLAS Discovery
Development, optimization, and calibration of human transient receptor potential (TRP) channel Ca2+ mobilization assays for TRPM8, TRPV1, and TRPA1 are described. Heterologous expression of hTRPM8 in HEK293T cells was required for anti-TRPM8 antibody staining and TRPM8 agonist induced Ca2+ mobilization signals which were both used to optimize ...
David A. Close, V. Blair Journigan, Paul A. Johnston   +2 more
openaire   +3 more sources

In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model

Journal of Pain Research, 2013
Eva Nyman,1,* Bo Franzén,1,* Andreas Nolting,1 Göran Klement,1 Gang Liu,1 Maria Nilsson,1 Annika Rosén,2 Charlotta Björk,3 Dirk Weigelt,4 Patrik Wollberg,1 Paul Karila,1 Patrick Raboisson11Neuroscience, Innovative ...
Nyman E, Franzén B, Nolting A, Klement G, Liu G, Nilsson M, Rosén A, Björk C, Weigelt D, Wollberg P, Karila P, Raboisson P   +11 more
doaj  

The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes

Frontiers in Pharmacology, 2017
Adipose tissue is an important endocrine organ in the human body. However, pathological overgrowth is associated with chronic illness. Regulation of adipogenesis and maturation of adipocytes via bioactive compounds in our daily diet has been in focus of ...
Barbara Lieder, Mathias Zaunschirm, Ann-Katrin Holik, Jakob P. Ley, Joachim Hans, Gerhard E. Krammer, Veronika Somoza, Veronika Somoza   +7 more
doaj   +1 more source

Selective activation of hTRPV1 by N-geranyl cyclopropylcarboxamide, an amiloride-insensitive salt taste enhancer.

PLoS ONE, 2014
TRPV1t, a variant of the transient receptor potential vanilloid-1 (TRPV1) has been proposed as a constitutively active, non-selective cation channel as a putative amiloride-insensitive salt taste receptor and shares many properties with TRPV1.
Min Jung Kim, Hee Jin Son, Yiseul Kim, Hae-Jin Kweon, Byung-Chang Suh, Vijay Lyall, Mee-Ra Rhyu   +6 more
doaj   +1 more source

The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel

Pharmacology Research & Perspectives
Methylisothiazolinone (MIT) is a known inducer of allergic contact dermatitis that is used as a preservative and a biocide in consumer products. Transient receptor potential ankyrin 1 (TRPA1) is a non‐selective cation channel expressed in neurons and in ...
Ilari Mäki‐Opas, Samu Luostarinen, Mari Hämäläinen, Katsuhiko Muraki, Eeva Moilanen   +4 more
doaj   +1 more source

Serum TRPA1 mediates the association between olfactory function and cognitive function

Frontiers in Aging Neuroscience
BackgroundOlfactory dysfunction was associated with poorer cognition. However, the association between transient receptor potential cation channel subfamily A member 1 (TRPA1) and cognitive function have not been studied. This study aimed to evaluate the
Xiaoniu Liang, Xiaoniu Liang, Xiaoniu Liang, Zhenxu Xiao, Zhenxu Xiao, Zhenxu Xiao, Jie Wu, Jie Wu, Jie Wu, Xiaoxi Ma, Xiaoxi Ma, Xiaoxi Ma, Qianhua Zhao, Qianhua Zhao, Qianhua Zhao, Ding Ding, Ding Ding, Ding Ding   +17 more
doaj   +1 more source

Resveratrol Reduces Hypoxia-Caused Increases of Apoptosis and Oxidative Neurotoxicity via TRPA1 Cation Channel Suppression in Glioblastoma Cells

Online Türk Sağlık Bilimleri Dergisi
Objective: Hypoxia (HPX) increases the amount of Ca2+ influx, apoptosis, and harmful free reactive oxygen species (ROS) in the brain and neurons. Resveratrol (RES) has been shown to reduce these increases in ROS-damaged neuronal cells by inhibiting voltage-gated Ca2+ channels.
openaire   +1 more source