Results 81 to 90 of about 1,414,547 (185)

Efeito antinociceptivo do eugenol em um modelo de dor muscular orofacial em camundongos: participação dos receptores glutamatérgicos, TRPs e ASICs [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2012As Disfunções Temporomandibulares (DTMs) compreendem um grupo de distúrbios que podem acometer os ...
Dal Bó, Wladmir Antônio de Souza
core  

TGF‐β1 Directly Sensitizes Capsaicin‐Sensitive Lung Vagal Neurons to Promote Airway Hypersensitivity

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Transforming growth factor‐β1 (TGF‐β1) is a pleiotropic cytokine implicated in the pathogenesis of inflammatory airway diseases such as asthma. Airway hypersensitivity (AHS), arising from sensitization of capsaicin‐sensitive lung vagal (CSLV) afferents, is a hallmark of these airway diseases.
Yueh‐Yin Chen, Nai‐Ju Chan, Chun‐Chun Hsu   +2 more
wiley   +1 more source

TRPA1 Activation-Induced Myelin Degradation Plays a Key Role in Motor Dysfunction After Intracerebral Hemorrhage

Frontiers in Molecular Neuroscience, 2019
Intracerebral hemorrhage (ICH) is a devastating disease that is characterized by high morbidity and high mortality. ICH has an annual incidence of 10–30/100,000 people and accounts for approximately 10%–30% of all types of stroke.
Min Xia, Weixiang Chen, Jie Wang, Yi Yin, Chao Guo, Chengcheng Li, Mingxi Li, Xiaoqin Tang, Zhengcai Jia, Rong Hu, Xin Liu, Hua Feng   +11 more
doaj   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis

Cell Reports, 2017
Candida albicans can enter skeletal tissue through a skin wound in an immunocompromised host or by contamination during orthopedic surgery. Such Candida osteomyelitis is accompanied by severe pain and bone destruction.
Kenta Maruyama, Yasunori Takayama, Takeshi Kondo, Ken-ichi Ishibashi, Bikash Ranjan Sahoo, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M. Martino, Hiroki Tanaka, Naohito Ohno, Yoichiro Iwakura, Naoki Takemura, Makoto Tominaga, Shizuo Akira   +13 more
doaj   +1 more source

Urinary Lipid Production Profile of Patients With Food Allergy

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 256-259, March 2025.
Sakura Masuko, Shinichiro Inagaki, Taiki Hamabata, Takeru Ishii, Nanae Nagata, Kiwako Yamamoto‐Hanada, Tatsuki Fukuie, Masami Narita, Tatsuo Shimosawa, Yukihiro Ohya, Takahisa Murata   +10 more
wiley   +1 more source

Roles of Interleukin‐31 in Allergen‐Driven Cough: Linking Protease‐Activated Receptor‐2 Activation and Vagal Ganglion Sensitization in a Dermatophagoides farinae‐Induced Asthma Model

Brain and Behavior, Volume 16, Issue 9, September 2026.
In a Dermatophagoides farinae‐induced asthma model, IL‐31 deficiency did not substantially alter airway inflammation or immune responses but prevented the allergen‐induced enhancement of PAR‐2 expression and responsiveness in vagal sensory neurons.
Takayoshi Miyamoto, Chiharu Ohira, Mao Kaneki, Mariko Komuro, Mana Ichikawa, Ibuki Yasuda, Yoshiichi Takagi, Tomoki Fukuyama   +7 more
wiley   +1 more source

Identifying Druggable Sites in the Pain-Sensing TRPA1 Ion Channel

, 2019
Transient receptor potential (TRP) channels, found in all eukaryotes, are a family of cation channels vital for critical physiological processes, such as mediating the sensation of unanticipated pain.
Skinner III, Kenneth Arthur
core   +4 more sources

Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1

SLAS Discovery
Development, optimization, and calibration of human transient receptor potential (TRP) channel Ca2+ mobilization assays for TRPM8, TRPV1, and TRPA1 are described. Heterologous expression of hTRPM8 in HEK293T cells was required for anti-TRPM8 antibody staining and TRPM8 agonist induced Ca2+ mobilization signals which were both used to optimize ...
David A. Close, V. Blair Journigan, Paul A. Johnston   +2 more
openaire   +3 more sources