Results 91 to 100 of about 1,414,547 (185)

In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model

Journal of Pain Research, 2013
Eva Nyman,1,* Bo Franzén,1,* Andreas Nolting,1 Göran Klement,1 Gang Liu,1 Maria Nilsson,1 Annika Rosén,2 Charlotta Björk,3 Dirk Weigelt,4 Patrik Wollberg,1 Paul Karila,1 Patrick Raboisson11Neuroscience, Innovative ...
Nyman E, Franzén B, Nolting A, Klement G, Liu G, Nilsson M, Rosén A, Björk C, Weigelt D, Wollberg P, Karila P, Raboisson P   +11 more
doaj  

Hyperdopaminergic States Bias Explorations–Exploitation Trade‐Off in Foraging and Impair Survival

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
Food scarcity causes lethal foraging due to foraging energy cost exceeding foraging energy gain. Hyperdopaminergic states (hypDA) increase lethal foraging due to increased energy cost and decreased energy gain under food scarcity conditions. ABSTRACT Dopamine plays central roles in reinforcement learning and motivation, allowing animals to evaluate ...
Wanhao Chi, Wenqin Fu, Cristianne R. M. Frazier, Liwen Xu, Jeff A. Beeler, Xiaoxi Zhuang   +5 more
wiley   +1 more source

The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes

Frontiers in Pharmacology, 2017
Adipose tissue is an important endocrine organ in the human body. However, pathological overgrowth is associated with chronic illness. Regulation of adipogenesis and maturation of adipocytes via bioactive compounds in our daily diet has been in focus of ...
Barbara Lieder, Mathias Zaunschirm, Ann-Katrin Holik, Jakob P. Ley, Joachim Hans, Gerhard E. Krammer, Veronika Somoza, Veronika Somoza   +7 more
doaj   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Exploring the epigenetic modifications of the RONS-TRPA1-CGRP axis in migraine pathophysiology

The Journal of Headache and Pain
Background Epigenetic studies in migraine provided results on the occurrence or lack of epigenetic modifications of genes whose products are important in migraine pathogenesis. However, these studies focus on single genes without analyzing how epigenetic
Michal Fila, Elzbieta Pawlowska, Jan Krekora, Maria Mitus-Kenig, Janusz Blasiak   +4 more
doaj   +1 more source

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd, Gerd Geisslinger, Brandes, Ralf P., Brandes, Ralf, Michael J Fischer, Fleming, Ingrid, Scholich, Klaus, Woolf Clifford J, Ralf P Brandes, Clifford J Woolf, Fleming Ingrid, Reeh, Peter Werner, Brenneis Christian, Fischer, Michael, Coste Ovidiu, Coste, Ovidiu, Brandes Ralf P, Kai Altenrath, Reeh Peter W, Christian Brenneis, Scholich Klaus, Sisignano, Marco, Reeh, Peter W., Altenrath Kai, Ingrid Fleming, Peter W Reeh, Woolf, Clifford J., Angioni Carlo, Geisslinger Gerd, Angioni, Carlo Federico, Klaus Scholich, Brenneis, Christian, Ovidiu Coste, Carlo Angioni, Sisignano Marco, Marco Sisignano, Fischer, Michael J., Fischer Michael J, Altenrath, Kai, Angioni, Carlo   +39 more
core   +3 more sources

MAMMALIAN TRANSIENT RECEPTOR POTENTIAL TRPA1 CHANNELS: FROM STRUCTURE TO DISEASE

, 2019
The transient receptor potential ankyrin (TRPA) channels are Ca2+-permeable nonselective cation channels remarkably conserved through the animal kingdom.
Boonen, Brett, Brett Boonen, Yeranddy A. Alpizar, Startek, Justyna B., Alvarez-Collazo, Julio, Alpizar, Yeranddy A., Julio Alvarez-Collazo, Talavera, Karel, Bernd Nilius, Naert, Robbe, Alicia Sanchez, Karel Talavera, Nilius, Bernd, AGUIAR ALPIZAR, Yeranddy, Robbe Naert, Alpizar, Yeranddy A, Justyna B. Startek, Startek, Justyna B, Sanchez, Alicia   +18 more
core   +1 more source

Selective activation of hTRPV1 by N-geranyl cyclopropylcarboxamide, an amiloride-insensitive salt taste enhancer.

PLoS ONE, 2014
TRPV1t, a variant of the transient receptor potential vanilloid-1 (TRPV1) has been proposed as a constitutively active, non-selective cation channel as a putative amiloride-insensitive salt taste receptor and shares many properties with TRPV1.
Min Jung Kim, Hee Jin Son, Yiseul Kim, Hae-Jin Kweon, Byung-Chang Suh, Vijay Lyall, Mee-Ra Rhyu   +6 more
doaj   +1 more source

Modulation of Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) Activity by Cdk5

, 2011
Our understanding of the molecular mechanisms for pain and temperature sensation has undergone a revolution in the last fifteen years through the characterization of receptors of the Transient Receptor Potential (TRP) superfamily.
Sulak, Michael A.
core  

TRPA1 kationcsatorna alanin mutánsainak létrehozása

, 2019
A tranziens receptor potenciál ankirin 1 (TRPA1) nem szelektív kationcsatorna, mely elnevezését a kiemelkedő hosszúságú ankirin ismétlődést tartalmazó doménjéről kapta, a TRPA alcsalád egyedüli tagja.
Buzás, Rebeka Franciska
core