Results 61 to 70 of about 1,414,547 (185)

Participação dos receptores glutamatérgicos e dos receptores de potencial transitório na ação antinociceptiva do (-)-Linalol [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010O objetivo do presente trabalho foi o de estender e confirmar a ação antinociceptiva do (-)-linalol ...
Batista, Patrícia Aparecida
core  

Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells

Journal of Pain Research, 2020
Jie Liu,1,* Kehua Que,1,* Yangqiu Liu,1 Chengcheng Zang,1 Jing Wen1,2 1Department of Endodontics, College of Stomatology, Tianjin Medical University, Tianjin, People’s Republic of China; 2Lotus Dental Clinic, Guangzhou, Guangdong Province, People ...
Liu J, Que K, Liu Y, Zang C, Wen J
doaj  

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Binding and Activating of Analgesic Crotalphine with Human TRPA1

Membranes
TRPA1 (Transient Receptor Potential Ankyrin 1), a cation channel predominantly expressed in sensory neurons, plays a critical role in detecting noxious stimuli and mediating pain signal transmission.
Mingmin Kang, Yanming Zhang, Xiufang Ding, Jianfu Xu, Xiaoyun Pang   +4 more
doaj   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

TRPA1 channel mediates organophosphate-induced delayed neuropathy

, 2017
The organophosphate-induced delayed neuropathy (OPIDN), often leads to paresthesias, ataxia and paralysis, occurs in the late-stage of acute poisoning or after repeated exposures to organophosphate (OP) insecticides or nerve agents, and may contribute to
Jian Li, Sui Fang, Bernard Attali, Qiang Ding, Youxin Wang, Xueqin Chen, Fuyun Tian, Xiang Xu, Xin Xie, Zhaobing Gao   +9 more
core   +1 more source

Bimodal action of menthol on the transient receptor potential channel TRPA1 [PDF]

, 2007
TRPA1 is a calcium-permeable nonselective cation transient receptor potential (TRP) channel that functions as an excitatory ionotropic receptor in nociceptive neurons. TRPA1 is robustly activated by pungent substances in mustard oil, cinnamon, and garlic
Damann, Nils, Segal Stanciu, Andrei, Voets, Thomas, Nilius, Bernd, Prenen, Jean, Talavera Pérez, Karel, Karashima, Yuji   +6 more
core   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Identification of Natural Compound Carnosol as a Novel TRPA1 Receptor Agonist

Molecules, 2014
The transient receptor potential ankyrin 1 (TRPA1) cation channel is one of the well-known targets for pain therapy. Herbal medicine is a rich source for new drugs and potentially useful therapeutic agents.
Chenxi Zhai, Qing Liu, Yuxin Zhang, Shifeng Wang, Yanling Zhang, Shiyou Li, Yanjiang Qiao   +6 more
doaj   +1 more source

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source