Results 1 to 10 of about 380,937 (310)

Unraveling proteomic signatures and neuroinflammatory networks in a CCI rat model of early sciatica: insights for neuropathic pain mechanisms [PDF]

Frontiers in Molecular Neuroscience
IntroductionSciatica is a prevalent and highly debilitating condition that is clinically characterized by pain radiating along the distribution of the sciatic nerve.
Xingjuan Li, Xiaojie Wang, Jinhui Song, Bin Jiang, Yaqin Wen, Yang Wang, Bo Liu, Xiao Zheng   +7 more
doaj   +2 more sources

Recovery of sweet taste preference in adult rats following bilateral chorda tympani nerve transection [PDF]

PeerJ, 2022
Background Numerous studies have noted the effect of chorda tympani (CT) nerve transection on taste sensitivity yet very few have directly observed its effects on taste receptor and taste signaling protein expressions in the tongue tissue.
Andrew Padalhin, Celine Abueva, So Young Park, Hyun Seok Ryu, Hayoung Lee, Jae Il Kim, Phil-Sang Chung, Seung Hoon Woo   +7 more
doaj   +2 more sources

Transection injury differentially alters the proteome of the human sural nerve

PLoS ONE, 2022
Regeneration after severe peripheral nerve injury is often poor. Knowledge of human nerve regeneration and the growth microenvironment is greatly lacking.
Monica J. Chau, Jorge E. Quintero, Eric Blalock, Stephanie Byrum, Samuel G. Mackintosh, Christopher Samaan, Greg A. Gerhardt, Craig G. van Horne   +7 more
doaj   +2 more sources

Using a Transection Paradigm to Enhance the Repair Mechanisms of an Investigational Human Cell Therapy

Cell Transplantation, 2022
One promising strategy in cell therapies for Parkinson’s disease (PD) is to harness a patient’s own cells to provide neuroprotection in areas of the brain affected by neurodegeneration. No treatment exists to replace cells in the brain.
Monica J. Chau, Jorge E. Quintero, Paula V. Monje, Stephen Randal Voss, Andrew S. Welleford, Greg A. Gerhardt, Craig G. van Horne   +6 more
doaj   +1 more source

Immunohistochemical localization of nerve injury-induced protein-1 in mouse tissues [PDF]

Anatomy & Cell Biology, 2019
Nerve injury-induced protein (Ninjurin)-1 is a cell adhesion molecule that is upregulated in neurons and Schwann cells after transection injury in rats. In this study, we investigated the localization of Ninjurin-1 in various tissues, including the cerebrum, sciatic nerve, spleen, lung, stomach, ileum, colon, liver, pancreas, kidney, testis, and skin ...
Poornima Ekanayake, Meejung Ahn, Jeongtae Kim, Yuna Choi, Taekyun Shin   +4 more
openaire   +2 more sources

Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates [PDF]

, 2020
Perturbations in skeletal muscle metabolism have been reported for a variety of neuromuscular diseases. However, the role of metabolism after constriction injury to a nerve and the associated muscle atrophy is unclear.
Afzal, Shoaib, Kempa, Stefan, Langer, Henning Tim, Spuler, Simone   +3 more
core   +2 more sources

Cell-free therapy based on extracellular vesicles: a promising therapeutic strategy for peripheral nerve injury

Stem Cell Research & Therapy, 2023
Peripheral nerve injury (PNI) is one of the public health concerns that can result in a loss of sensory or motor function in the areas in which injured and non-injured nerves come together.
Mojdeh Salehi Namini, Fatemeh Daneshimehr, Nima Beheshtizadeh, Vahid Mansouri, Jafar Ai, Hossein Kargar Jahromi, Somayeh Ebrahimi-Barough   +6 more
doaj   +1 more source

Spike Generators and Cell Signaling in the Human Auditory Nerve: An Ultrastructural, Super-Resolution, and Gene Hybridization Study

Frontiers in Cellular Neuroscience, 2021
Background: The human auditory nerve contains 30,000 nerve fibers (NFs) that relay complex speech information to the brain with spectacular acuity. How speech is coded and influenced by various conditions is not known.
Wei Liu, Maria Luque, Hao Li, Anneliese Schrott-Fischer, Rudolf Glueckert, Sven Tylstedt, Gunesh Rajan, Gunesh Rajan, Hanif Ladak, Sumit Agrawal, Helge Rask-Andersen   +10 more
doaj   +1 more source

Collagen‐rich deposit formation in the sciatic nerve after injury and surgical repair: A study of collagen‐producing cells in a rabbit model

Brain and Behavior, 2020
Introduction Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to span the gap between the stumps of ...
Jolanta Fertala, Michael Rivlin, Mark L. Wang, Pedro K. Beredjiklian, Andrzej Steplewski, Andrzej Fertala   +5 more
doaj   +1 more source

Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing. [PDF]

PLoS ONE, 2010
Wound healing is a complex dynamic process characterised by a uniform flow of events in nearly all types of tissue damage, from a small skin scratch to myocardial infarction.
Wilbert P Vermeij, Claude Backendorf
doaj   +1 more source