Results 1 to 10 of about 11,557,555 (285)

Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain

Neural Plasticity, 2020
Chronic pathological pain is one of the most intractable clinical problems faced by clinicians and can be devastating for patients. Despite much progress we have made in understanding chronic pain in the last decades, its underlying mechanisms remain ...
Zhi-Chuan Sun, Sui-Bin Ma, Wen-Guang Chu, Dong Jia, Ceng Luo   +4 more
doaj   +1 more source

Permeation and Rectification in Canonical Transient Receptor Potential-6 (TRPC6) Channels

Frontiers in Physiology, 2018
Transient receptor potential-6 channels are widely expressed cation channels that play a role in regulating Ca2+ dynamics, especially during G protein-coupled receptor signaling.
Stuart E. Dryer, Stuart E. Dryer, Eun Young Kim   +2 more
doaj   +1 more source

Bidirectional crosstalk between TRP channels and Toll-like receptors in inflammation and host defense

Journal of Neuroinflammation
Integrating physicochemical environmental cues with pathogen detection is essential for an effective and balanced host defense. While Toll-like receptors (TLRs) detect pathogen-associated molecular patterns (PAMPs), transient receptor potential (TRP) ion
Qianrui Zeng, Chi Zhang, Na Xie, Shutong Chen, Chang Liu, Haodang Luo, Xiaoxing You   +6 more
doaj   +1 more source

TRPA1 and TRPM8 in Allergic Rhinitis and Chronic Rhinosinusitis: Emerging Role in Neuroimmune Inflammation

Biomedicines
Nasal hyperreactivity (NHR) is a core symptom of allergic rhinitis (AR) and chronic rhinosinusitis (CRS), frequently induced by cold stimuli. Accumulating evidence indicates that NHR is largely mediated by neuroimmune mechanisms rather than classical ...
Tianhui Kang, Zijun Qiu, Surita Aodeng, Yuzhuo Liu, Zhenzhen Zhu, Wei Lv   +5 more
doaj   +1 more source

Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis

Molecular Pain, 2017
Transient Receptor Potential Vanilloid 1 (TRPV1) and Transient Receptor Potential Ankyrin 1 (TRPA1) expressed mainly by primary sensory neurons function as major nociceptive integrators.
Noémi Bohonyi, Krisztina Pohóczky, Bálint Szalontai, Anikó Perkecz, Krisztina Kovács, Béla Kajtár, Lajos Orbán, Tamás Varga, Sarolta Szegedi, József Bódis, Zsuzsanna Helyes, Miklós Koppán   +11 more
doaj   +1 more source

Emerging Role of Mucolipins TRPML Channels in Cancer

Frontiers in Oncology, 2020
Giorgio Santoni, Matteo Santoni, Federica Maggi, Federica Maggi, Oliviero Marinelli, Oliviero Marinelli, Maria Beatrice Morelli   +6 more
doaj   +1 more source

Transient receptor potential canonical (TRPC) channels in diabetes and associated complications

Channels
TRPC channels are widely expressed in various tissues and cell types, and accumulating evidence indicates that they play critical roles in pancreatic β cell function, including the regulation of insulin secretion.
Yi Wu, Shengming Chen, Xiaolu Xia
doaj   +1 more source

Differing endometrial expression of calcium modulating transient receptor potential channels

Journal of Translational Medicine, 2021
Maryam Ghavideldarestani, Alexandra E. Butler, Stephen L. Atkin   +2 more
doaj   +1 more source

Editorial: Transient receptor potential (TRP) ion channels in non-excitable cells

Frontiers in Physiology, 2023
Mustafa Nazıroğlu, Mustafa Nazıroğlu, Beatrice Mihaela Radu, Dana Cucu   +3 more
doaj   +1 more source

Two Transient Receptor Potential Channels at Focal Adhesions. [PDF]

J Histochem Cytochem, 2023
Mitsou I, Carlson CR, Multhaupt HAB, Brakebusch C, Couchman JR.   +4 more
europepmc   +1 more source