Results 41 to 50 of about 11,557,555 (285)
Cardiology Journal, 2020 BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation,
Min-Soo Ahn +12 more
doaj +1 more source
A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]
, 2013 TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars +19 more
core +2 more sources
Temperature activated transient receptor potential ion channels from Antarctic fishes
Open Biology, 2023 Antarctic notothenioid fishes (cryonotothenioids) live in waters that range between −1.86°C and an extreme maximum +4°C. Evidence suggests these fish sense temperature peripherally, but the molecular mechanism of temperature sensation in unknown ...
Julia M. York
doaj +1 more source
Transient receptor potential (TRP) channels in human colorectal cancer: evidence and perspectives [PDF]
, 2021 Colorectal cancer (CRC) is one of the leading causes of death in the civilized world. Transient receptor potential channels (TRPs) are a heterogeneous family of cation channels that play an important role in gastrointestinal physiology.
Rizopoulos, Theodoros +1 more
core +1 more source
Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future
Frontiers in Neuroscience, 2023 Ultrasound neuromodulation technology is a promising neuromodulation approach, with the advantages of noninvasiveness, high-resolution, deep penetration and good targeting, which aid in circumventing the side effects of drugs and invasive therapeutic ...
Mengyao Song +9 more
doaj +1 more source
Transient Receptor Potential Channels in the Vasculature
Physiological Reviews, 2015 The mammalian genome encodes 28 distinct members of the transient receptor potential (TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for different ionic species. Multiple TRP channels are present in all cells and are involved in diverse aspects of cellular function, including sensory perception ...
Scott, Earley, Joseph E, Brayden
openaire +3 more sources
Transient receptor potential ion channels control thermoregulatory behaviour in reptiles. [PDF]
PLoS ONE, 2007 Biological functions are governed by thermodynamics, and animals regulate their body temperature to optimise cellular performance and to avoid harmful extremes.
Frank Seebacher, Shauna A Murray
doaj +1 more source
Transient receptor potential channels in multiple myeloma. [PDF]
Oncol Lett, 2022 Multiple myeloma is the second most commonly diagnosed hematologic malignancy. As an incurable disease, the molecular mechanisms underlying its many aspects remain unclear. Intracellular calcium ion is an essential signaling molecule that modulates malignant cell behavior, and abnormal regulation of cellular calcium homeostasis may promote cancer cell ...
Meng L, Gu G, Bi L.
europepmc +4 more sources
Transient Receptor Potential Channels and Auditory Functions. [PDF]
Antioxid Redox Signal, 2022 Significance: Transient receptor potential (TRP) channels are cation-gated channels that serve as detectors of various sensory modalities, such as pain, heat, cold, and taste. These channels are expressed in the inner ear, suggesting that they could also contribute to the perception of sound.
Ramkumar V +5 more
europepmc +3 more sources
The transient receptor potential family of ion channels [PDF]
Genome Biology, 2011 The transient receptor potential (TRP) multigene superfamily encodes integral membrane proteins that function as ion channels. Members of this family are conserved in yeast, invertebrates and vertebrates. The TRP family is subdivided into seven subfamilies: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin ...
Nilius, Bernd, Owsianik, Grzegorz
openaire +2 more sources