Results 41 to 50 of about 103,120 (254)
TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases
Frontiers in Molecular Biosciences, 2022 Transient receptor potential (TRP) channels are polymodal channels capable of sensing environmental stimuli, which are widely expressed on the plasma membrane of cells and play an essential role in the physiological or pathological processes of cells as ...
Yusheng Liu, Yihan Lyu, Hongmei Wang
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Transient Receptor Potential Channels and Metabolism.
Molecules and cells, 2019 Transient receptor potential (TRP) channels are nonselective cationic channels, conserved among flies to humans. Most TRP channels have well known functions in chemosensation, thermosensation, and mechanosensation. In addition to being sensing environmental changes, many TRP channels are also internal sensors that help maintain homeostasis.
Dhakal, Subash, Lee, Youngseok
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Frontiers in Physiology, 2022 Lipids modulate the function of many ion channels, possibly through direct lipid-protein interactions. The recent outpouring of ion channel structures by cryo-EM has revealed many lipid binding sites.
Wayland W. L. Cheng +2 more
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Roles of transient receptor potential channels in pain [PDF]
Brain Research Reviews, 2009 Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in ...
Cheryl L, Stucky +5 more
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TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes
Frontiers in Physiology, 2022 Transient receptor potential canonical 1 (TRPC1) channels are Ca2+-permeable ion channels expressed in cardiomyocytes. An involvement of TRPC1 channels in cardiac diseases is widely established.
Molly E. Streiff +8 more
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Canonical transient receptor potential channels in diabetes [PDF]
Experimental Biology and Medicine, 2012 Canonical transient receptor potential (TRPC) channel proteins have been identified as downstream molecules in a G protein-coupled receptor signaling pathway and are involved in a variety of cell functions due to their ability to regulate intracellular calcium signaling.
Sarabeth, Graham +2 more
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Journal of Pharmacological Sciences, 2020 Cellular dielectric spectroscopy (CDS) is a novel technology enabling pharmacological evaluation of multiple receptor types with a label-free cell-based assay.
Kanako Miyano +11 more
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Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels
Cells, 2023 Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation permeable channel that plays an essential role in calcium signalling.
Bethan A. Cole, Esther B. E. Becker
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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Frontiers in Physiology, 2021 Pain by chemical irritants is one of the less well-described aspects of nociception. The acidic substance is the paradigm of the chemical noxious compound. An acidic insult on cutaneous, subcutaneous and muscle tissue results in pain sensation.
Omar Páez +5 more
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