Results 41 to 50 of about 108,113 (287)
Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation
Frontiers in Immunology, 2020 Transient receptor potential (TRP) channels are a superfamily of non-selective cation channels that act as polymodal sensors in many tissues throughout mammalian organisms.
Harold A. Silverman +11 more
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Biomedicines, 2022 Background: Atrial fibroblasts activation causes atrial fibrosis, which is one major pathophysiological contributor to atrial fibrillation (AF) genesis.
Yuan Hung +6 more
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Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts
Pharmaceuticals, 2017 2017 marks the 20th anniversary of the molecular cloning by David Julius and colleagues (1997) of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1) [1].
Susan Huang, Arpad Szallasi
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The role of transient receptor potential channels in joint diseases [PDF]
European Cells & Materials, 2017 ransient receptor potential channels (TRP channels) are cation selective transmembrane receptors with diverse structures, activation mechanisms and physiological functions.
O Krupkova, J Zvick, K Wuertz-Kozak
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Functional expression of TRPV4 channels in human collecting duct cells : implications for secondary hypertension in diabetic nephropathy [PDF]
, 2012 Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress.
Hills, Claire E. +2 more
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Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases
Frontiers in Pharmacology, 2021 Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series of dermatologic diseases. A large variety of biological events and bioactive molecules are involved in the process of skin wound healing and functional recovery ...
Min Wang +6 more
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Transient Receptor Potential (TRP) Channels in Health and Disease
Cells, 2019 Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel, now named TRPC1, was cloned and published (reviewed in [...]
Alexander Dietrich
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Pharmaceuticals, 2023 Given the unique expression patterns and revelations of its critical involvement in a host of neurological disorders, the TRPC1/4/5 subgroup has become an intense target of drug development, and some compounds are now in clinical trials.
Kevin D. Phelan +2 more
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Roles of transient receptor potential channels in pain [PDF]
Brain Research Reviews, 2009 Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious stimuli and transduce a diverse range of physical and chemical energy into action potentials in ...
Cheryl L, Stucky +5 more
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Transient receptor potential (TRP) gene superfamily encoding cation channels
Human Genomics, 2011 Transient receptor potential (TRP) non-selective cation channels constitute a superfamily, which contains 28 different genes. In mammals, this superfamily is divided into six subfamilies based on differences in amino acid sequence homology between the ...
Pan Zan, Yang Hua, Reinach Peter S
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